Home LiteratureArticle Details

PMID: 3899003 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.

Antimicrobial agents and chemotherapy ·Vol. 28 ·No. 1 ·1985-07-00 ·Pages 163-4

Llaneza J, Villar CJ, Salas JA, Suarez JE, Mendoza MC, Hardisson C

Abstract

The molecular mechanism of plasmid-mediated resistance to fosfomycin is described. The antibiotic was inactivated intracellularly and remained inside the cells. Modification was also obtained from cell extracts and was not energy dependent. The modifying enzyme seems to have sulfhydryl groups in its active center.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Enterobacteriaceae/drug effects,enzymology,genetics Escherichia coli/genetics Fosfomycin/metabolism,pharmacology Plasmids R Factors

Chemicals

Anti-Bacterial Agents Fosfomycin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Llaneza J

Villar C J

Salas J A

Suarez J E

Mendoza M C

Hardisson C

References (7)

7 references, click to expand

Plasmid-determined resistance to fosfomycin in Serratia marcescens.
Antimicrob Agents Chemother. 1980 Aug;18(2):215-9 PMID: 7004337
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.
Antimicrob Agents Chemother. 1982 Apr;21(4):608-12 PMID: 7044304
The mechanism of action of fosfomycin (phosphonomycin).
Ann N Y Acad Sci. 1974 May 10;235(0):364-86 PMID: 4605290
Charactertization of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitro.
J Antibiot (Tokyo). 1975 Nov;28(11):906-11 PMID: 1104551
[Prevalence and dispersion of plasmids conferring fosfomycin resistance in enterobacteria].
Pathol Biol (Paris). 1984 Sep;32(7):755-8 PMID: 6387596
Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.
Antimicrob Agents Chemother. 1983 Aug;24(2):276-8 PMID: 6357073
Cloning and expression in minicells of the determinant of resistance to fosfomycin from the transposon Tn2921.
Plasmid. 1984 May;11(3):243-7 PMID: 6087392

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.28.1.163

Published

1985-07-00

Pages

163-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC176334

Subset

External Links

PubMed source DOI: 10.1128/AAC.28.1.163 PMC Full Text View journal details

Analysis Services

Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.

Contact

WeChat Official Account