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PMID: 3872459 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 7 ·1985-04-00 ·Pages 1994-8

Jonas V, Lin CR, Kawashima E, Semon D, Swanson LW, Mermod JJ, Evans RM, Rosenfeld MG

Abstract

Two mRNAs generated as a consequence of alternative RNA processing events in expression of the human calcitonin gene encode the protein precursors of either calcitonin or calcitonin gene-related peptide (CGRP). Both calcitonin and CGRP RNAs and their encoded peptide products are expressed in the human pituitary and in medullary thyroid tumors. On the basis of sequence comparison, it is suggested that both the calcitonin and CGRP exons arose from a common primordial sequence, suggesting that duplication and rearrangement events are responsible for the generation of this complex transcription unit.

MeSH Terms
Base Sequence Calcitonin/genetics Calcitonin Gene-Related Peptide Humans Nerve Tissue Proteins/genetics Pituitary Gland/analysis RNA Processing, Post-Transcriptional RNA, Messenger/analysis
Chemicals
Nerve Tissue Proteins RNA, Messenger Calcitonin Calcitonin Gene-Related Peptide
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Jonas V
Lin C R
Kawashima E
Semon D
Swanson L W
Mermod J J
Evans R M
Rosenfeld M G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.7.1994
Published
1985-04-00
Pages
1994-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397471
Subset
IM
Databases
GENBANK
M11303, M12664, M12665, M12666, M12667
External Links
PubMed source DOI: 10.1073/pnas.82.7.1994 PMC Full Text View journal details
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