Family study on the polymorphisms of the sixth and seventh components (C6 and C7) of human complement: linkage and haplotype analyses.

American journal of human genetics ·Vol. 39 ·No. 3 ·1986-09-00 ·Pages 414-9

Tokunaga K, Dewald G, Omoto K, Juji T

Abstract

Genetic polymorphisms of the sixth and seventh complement components (C6 and C7) have been studied in Japanese family material using polyacrylamide gel isoelectric focusing followed by immunoblotting. Three common and four rare alleles were observed at the locus for C6. Inheritance of the two rare C6 variants, M11 and B3, was first confirmed. Three common C7 allotypes were classified as C7 1, C7 2, and C7 4, respectively. Linkage analysis confirmed the close linkage between the loci for C6 and C7. The maximum lod score was 8.43 at phi = 0 (95% confidence limits: phi = 0 and phi = .07). No significant linkage disequilibrium was found between C6 and C7 in directly determined haplotypes of unrelated parents.

MeSH Terms

Alleles Complement C6/genetics Complement C7/genetics Female Genetic Linkage Humans Lod Score Male Polymorphism, Genetic

Chemicals

Complement C6 Complement C7

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tokunaga K

Dewald G

Omoto K

Juji T

References (15)

15 references, click to expand

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Article Info

Journal

American journal of human genetics

Abbr.

Am J Hum Genet

ISSN

0002-9297

Published

1986-09-00

Pages

414-9

Language

English

Region

United States

NLM ID

0370475

PMCID

PMC1683954

Subset

External Links

PubMed source PMC Full Text View journal details

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Family study on the polymorphisms of the sixth and seventh components (C6 and C7) of human complement: linkage and haplotype analyses.

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