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PMID: 3157763 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human genes for three complement components that regulate the activation of C3 are tightly linked.

The Journal of experimental medicine ·Vol. 161 ·No. 5 ·1985-05-01 ·Pages 1189-95

Rodriguez de Cordoba S, Lublin DM, Rubinstein P, Atkinson JP

Abstract

A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibility complex, which contains the genes for the complement components, C4, C2, and factor B, or to the C3 locus. These data further suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system.

MeSH Terms
Carrier Proteins/genetics Complement Activation Complement C2/genetics Complement C3/genetics,immunology,metabolism Complement C3b Inactivator Proteins/genetics Complement C4/genetics Complement C4a Complement C4b Complement Factor B/genetics Complement Factor H Complement Inactivator Proteins Genes Genes, MHC Class II Genetic Linkage Glycoproteins Humans Receptors, Complement/genetics Receptors, Complement 3b
Chemicals
CFH protein, human Carrier Proteins Complement C2 Complement C3 Complement C3b Inactivator Proteins Complement C4 Complement Inactivator Proteins Glycoproteins Receptors, Complement Receptors, Complement 3b Complement C4a Complement C4b Complement Factor H Complement Factor B
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rodriguez de Cordoba S
Lublin D M
Rubinstein P
Atkinson J P
References (22)
22 references, click to expand
  1. Genetic polymorphism and linkage of the sixth and seventh complement components (C6 and C7) in the common marmoset.
    Biochem Genet. 1984 Feb;22(1-2):51-63 PMID: 6424644
  2. Genetic polymorphism of human C4-binding protein.
    J Immunol. 1983 Sep;131(3):1565-9 PMID: 6886425
  3. Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3794-8 PMID: 6943584
  4. Strategies for multilocus linkage analysis in humans.
    Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 PMID: 6587361
  5. Polymorphism of human erythrocyte C3b/C4b receptor.
    Proc Natl Acad Sci U S A. 1983 Mar;80(6):1698-702 PMID: 6572933
  6. Immunofixation electrophoresis: a technique for the study of protein polymorphism.
    Vox Sang. 1969 Nov;17(5):445-52 PMID: 4188201
  7. Linkage group I: the simultaneous estimation of recombination and interference.
    Cytogenet Cell Genet. 1976;16(1-5):335-9 PMID: 975904
  8. Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes.
    J Exp Med. 1982 Dec 1;156(6):1739-54 PMID: 7175439
  9. Defective immune-adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus.
    Lancet. 1981 Sep 5;2(8245):493-7 PMID: 6115248
  10. Inherited structural variation and linkage relationships of C7.
    J Immunogenet. 1978 Jun;5(3):157-63 PMID: 690473
  11. High resolution isoelectric focusing of immunoprecipitated proteins under denaturing conditions. A simple analytical method applied to the study of complement component polymorphisms.
    J Immunol Methods. 1984 Apr 27;69(2):165-72 PMID: 6232323
  12. Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes).
    Vox Sang. 1983;45(1):62-7 PMID: 6554026
  13. Genetic mapping of mouse C4-bp locus to the H-2D-Qa interval.
    J Immunol. 1984 Jan;132(1):6-8 PMID: 6690609
  14. The complement components of the major histocompatibility locus.
    CRC Crit Rev Biochem. 1984;16(1):1-19 PMID: 6232112
  15. Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus.
    J Exp Med. 1982 May 1;155(5):1427-38 PMID: 6978375
  16. The genetics of the sixth and seventh components of complement in the dog: polymorphism, linkage, locus duplication, and silent alleles.
    Biochem Genet. 1983 Feb;21(1-2):81-91 PMID: 6838492
  17. Evaluation of linkage of the human C3b/C4b receptor to HLA.
    J Immunol. 1984 May;132(5):2168-9 PMID: 6232312
  18. Autosomal linkage in humans (methodology and results of computer analysis).
    Ser Haematol. 1975;8(2):153-237 PMID: 1198129
  19. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants.
    Nature. 1976 Aug 26;262(5571):795-7 PMID: 785284
  20. Mode of inheritance of decreased C3b receptors on erythrocytes of patients with systemic lupus erythematosus.
    N Engl J Med. 1982 Oct 14;307(16):981-6 PMID: 7110302
  21. Genetic regulation of a structural polymorphism of human C3b receptor.
    J Clin Invest. 1983 Aug;72(2):685-93 PMID: 6223944
  22. Genetic polymorphism of human factor H (beta 1H).
    J Immunol. 1984 Apr;132(4):1906-8 PMID: 6230396
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.161.5.1189
Published
1985-05-01
Pages
1189-95
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187593
Subset
IM
Grants
NHLBI NIH HHS · HL-09011 · United States
External Links
PubMed source DOI: 10.1084/jem.161.5.1189 PMC Full Text View journal details
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