Activation of the alternative complement pathway by a streptococcal lipoteichoic acid.

Infection and immunity ·Vol. 22 ·No. 1 ·1978-10-00 ·Pages 286-7

Fiedel BA, Jackson RW

Abstract

A glycerol lipoteichoic acid antigen from Streptococcus pyogenes 1-RP41 was found by rabbit erythrocyte hemolytic assay to activate the alternative complement pathway in human sera. Over a narrow concentration range of the teichoic acid, complement consumption was dose dependent, whereas at higher concentrations of the acid complement consumption could not be detected.

MeSH Terms

Antigens, Bacterial/immunology Complement Activation Complement Pathway, Alternative Complement System Proteins/metabolism Lipopolysaccharides Phosphatidic Acids/immunology Streptococcus pyogenes/immunology Teichoic Acids/immunology

Chemicals

Antigens, Bacterial Lipopolysaccharides Phosphatidic Acids Teichoic Acids lipoteichoic acid Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fiedel B A

Jackson R W

References (7)

7 references, click to expand

Activation of the alternative complement pathway by pneumococcal cell wall teichoic acid.
J Immunol. 1978 Jan;120(1):174-8 PMID: 24071
Induction of nephrocalcinosis in rabbit kidneys after long-term exposure to a streptococcal teichoic acid.
Infect Immun. 1977 Sep;17(3):665-7 PMID: 332635
Immunogenicity of a purified and carrier-complexed streptococcal lipoteichoic acid.
Infect Immun. 1976 Jun;13(6):1585-90 PMID: 786876
Complement activation by interaction of polyanions and polycations.
Immunology. 1976 Feb;30(2):161-9 PMID: 1262050
The effect of a streptococcus pyogenes teichoic acid on the immune response of mice.
J Immunol. 1973 Jan;110(1):148-56 PMID: 4568179
Effects of a streptococcal lipoteichoic acid on host responses in mice.
Infect Immun. 1976 May;13(5):1408-17 PMID: 773834
Activation of the alternate pathway of human complements by rabbit cells.
J Immunol. 1974 Jul;113(1):348-58 PMID: 4134064

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.22.1.286-287.1978

Published

1978-10-00

Pages

286-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422147

Subset

External Links

PubMed source DOI: 10.1128/iai.22.1.286-287.1978 PMC Full Text View journal details

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Activation of the alternative complement pathway by a streptococcal lipoteichoic acid.

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