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PMID: 786876 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunogenicity of a purified and carrier-complexed streptococcal lipoteichoic acid.

Infection and immunity ·Vol. 13 ·No. 6 ·1976-06-00 ·Pages 1585-90

Fiedel BA, Jackson RW

Abstract

Solublie teichoic acid could not stimulate the formation of antibodies either as an aqueous solution or in an emulsion with Freund incomplete adjuvant. However, when given as precipitates with methylated bovine serum albumin, it stimulated strong anti-teichoic acid responses. High levels of anti-teichoic acid antibodies usually resulted in allergic symptoms upon secondary challenge either with immunogenic teichoic acid-methylated bovine albumin complexes or with non-immunogenic soluble teichoic acid. These symptoms suggested anaphylatic shock, but probably also included the formation of complement-consuming immune complexes.

MeSH Terms
Adjuvants, Immunologic Anaphylaxis/immunology Animals Antibody Formation Antigens, Bacterial Female Male Rabbits Serum Albumin, Bovine/immunology Streptococcus pyogenes/immunology Teichoic Acids/immunology
Chemicals
Adjuvants, Immunologic Antigens, Bacterial Teichoic Acids Serum Albumin, Bovine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fiedel B A
Jackson R W
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22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.13.6.1585-1590.1976
Published
1976-06-00
Pages
1585-90
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420804
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.13.6.1585-1590.1976 PMC Full Text View journal details
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