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PMID: 359750 Published · ppublish English Journal Article

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

The Journal of experimental medicine ·Vol. 148 ·No. 4 ·1978-10-01 ·Pages 878-89

Hall BM, Dorsch S, Roser B

Abstract

The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.

MeSH Terms
B-Lymphocytes/immunology Cell Movement Cell Survival Cytotoxicity, Immunologic Gamma Rays Graft Rejection/radiation effects Heart Transplantation Lymph Nodes/immunology Spleen/immunology T-Lymphocytes/immunology Thymus Gland/immunology Transplantation, Homologous
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hall B M
Dorsch S
Roser B
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30 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.148.4.878
Published
1978-10-01
Pages
878-89
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185031
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.148.4.878 PMC Full Text View journal details
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