Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte.

The Journal of experimental medicine ·Vol. 116 ·1962-08-01 ·Pages 177-86

ARNASON BG, JANKOVIC BD, WAKSMAN BH, WENNERSTEN C

Abstract

In rats thymectomized at birth and tested in adult life, ability to develop autoallergic encephalomyelitis was completely suppressed, there was a marked diminution in the degree of tuberculin sensitization appearing after a single injection of mycobacteria in oil, rejection of skin homografts was markedly delayed, and adjuvant arthritis was not appreciably affected. At the same time there was a striking decrease in the circulating level of small lymphocytes.

Keywords

LYMPHOCYTES/physiology THYMUS GLAND/physiology

MeSH Terms

Animals Hypersensitivity Lymphocytes/physiology Rats Thymectomy Thymus Gland/physiology

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

ARNASON B G

JANKOVIC B D

WAKSMAN B H

WENNERSTEN C

References (9)

9 references, click to expand

The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type.
J Exp Med. 1961 Dec 1;114:997-1022 PMID: 14004486
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease.
J Exp Med. 1961 Mar 1;113:485-510 PMID: 13733780
Immunological function of the thymus.
Lancet. 1961 Sep 30;2(7205):748-9 PMID: 14474038
Skin homograft survival in thymectomized mice.
Proc Soc Exp Biol Med. 1962 Jan;109:193-6 PMID: 14470489
Passive transfer of tuberculin sensitivity by tritiated thymidine-labeled lymphoid cells.
J Exp Med. 1961 Nov 1;114:779-90 PMID: 14478054
Role of the thymus in immune ractions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth.
J Exp Med. 1962 Aug 1;116:159-76 PMID: 14451146
Encephalomyelitis in the rat following intracutaneous injection of central nervous system tissue with adjuvant.
Proc Soc Exp Biol Med. 1952 Oct;81(1):260-1 PMID: 13047376
A method of studying leukocytic functions in vivo.
Ann N Y Acad Sci. 1955 Mar 24;59(5):757-805 PMID: 13259351
Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organs of thymectomized rats.
J Exp Med. 1962 Aug 1;116:187-206 PMID: 14004487

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.116.2.177

Published

1962-08-01

Pages

177-86

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137389

Subset

External Links

PubMed source DOI: 10.1084/jem.116.2.177 PMC Full Text View journal details

Analysis Services

Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte.

Contact

WeChat Official Account