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PMID: 3592790 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of iron chelation on inflammatory joint disease.

Annals of the rheumatic diseases ·Vol. 46 ·No. 4 ·1987-04-00 ·Pages 327-33

Andrews FJ, Morris CJ, Kondratowicz G, Blake DR

Abstract

Mild iron deficiency induced by treatment with the iron chelator desferrioxamine reduced the incidence and severity of joint inflammation associated with adjuvant disease in rats but did not alter the local primary inflammatory response or the systemic sequelae. Both rats treated with desferrioxamine and control rats showed increased levels of alpha 1 acid glycoprotein, characteristic pathological changes in the liver and inguinal lymph nodes, and the primary inflammatory response at the site of injection. Histology, microfocal radiography, and gross assessment of the joints, however, showed a suppression or reduction in soft tissue swelling and bone erosion in the rats treated with desferrioxamine. This is a novel observation suggesting an apparently selective influence of iron on joint mediated inflammation.

MeSH Terms
Animals Arthritis/drug therapy Arthritis, Experimental/blood,drug therapy,pathology Deferoxamine/therapeutic use Liver/pathology Lymph Nodes/pathology Male Orosomucoid/metabolism Rats Rats, Inbred Strains
Chemicals
Orosomucoid Deferoxamine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Andrews F J
Morris C J
Kondratowicz G
Blake D R
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30 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.46.4.327
Published
1987-04-00
Pages
327-33
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1002129
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.46.4.327 PMC Full Text View journal details
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