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PMID: 3546142 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice.

Infection and immunity ·Vol. 55 ·No. 3 ·1987-03-00 ·Pages 816-21

Udhayakumar V, Muthukkaruppan VR

Abstract

Outer membrane proteins (OMP) extracted from both smooth (C5) and rough (Rb2) strains of Salmonella typhimurium were able to induce protective immunity to salmonellosis. The OMP-induced protection lasted for at least 6 months. The antibody level was estimated by passive hemagglutination. In the C5 OMP-immunized mice, antibodies to both proteins and lipopolysaccharide were detected. On the other hand, in the Rb2 OMP-immunized mice, antiprotein but not antilipopolysaccharide antibodies were detected. Delayed-type hypersensitivity appeared as early as the second week after immunization with OMP and persisted through the fourth week.

MeSH Terms
Animals Antibodies, Bacterial/biosynthesis Bacterial Outer Membrane Proteins/immunology,isolation & purification Bacterial Vaccines/immunology,isolation & purification Immunity, Cellular Immunization Lipopolysaccharides/immunology Mice Mice, Inbred BALB C Salmonella Infections, Animal/microbiology,prevention & control Salmonella typhimurium/analysis,immunology,isolation & purification
Chemicals
Antibodies, Bacterial Bacterial Outer Membrane Proteins Bacterial Vaccines Lipopolysaccharides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Udhayakumar V
Muthukkaruppan V R
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34 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.55.3.816-821.1987
Published
1987-03-00
Pages
816-21
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260415
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.55.3.816-821.1987 PMC Full Text View journal details
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