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PMID: 3526330 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 15 ·1986-08-00 ·Pages 5459-63

Semba K, Nishizawa M, Miyajima N, Yoshida MC, Sukegawa J, Yamanashi Y, Sasaki M, Yamamoto T, Toyoshima K

Abstract

An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.

MeSH Terms
Amino Acid Sequence Base Sequence Chromosomes, Human, 6-12 and X Cloning, Molecular DNA/genetics Gene Expression Regulation Humans Protein-Tyrosine Kinases/genetics Proto-Oncogene Proteins/genetics Proto-Oncogenes
Chemicals
Proto-Oncogene Proteins DNA Protein-Tyrosine Kinases
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Semba K
Nishizawa M
Miyajima N
Yoshida M C
Sukegawa J
Yamanashi Y
Sasaki M
Yamamoto T
Toyoshima K
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.15.5459
Published
1986-08-00
Pages
5459-63
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386306
Subset
IM
Databases
GENBANK
M14333
External Links
PubMed source DOI: 10.1073/pnas.83.15.5459 PMC Full Text View journal details
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