Home LiteratureArticle Details

PMID: 3475232 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse.

Genetics ·Vol. 116 ·No. 3 ·1987-07-00 ·Pages 465-8

Keitges EA, Schorderet DF, Gartler SM

Abstract

Dosage studies and the inheritance pattern of the gene for steroid sulfatase (Sts) in the mouse have previously provided indirect evidence for a functional Y-linked allele which recombines obligatorily with its X-linked allele in male meiosis. In this study, we have investigated the linkage relationship of Sts and the sex-reversed mutation (Sxr), a gene which is known to reside in the pairing region of the Y chromosome. The results clearly demonstrate that Sxr and Sts are linked in a region of obligatory recombination and Sts maps proximal to Sxr with most recombinants occurring proximal to the two genes.

MeSH Terms

Alleles Animals Genetic Linkage Mice Recombination, Genetic Sex Chromosomes Sex Determination Analysis Steryl-Sulfatase Sulfatases/genetics

Chemicals

Sulfatases Steryl-Sulfatase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Keitges E A

Schorderet D F

Gartler S M

References (15)

15 references, click to expand

X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome.
Lancet. 1966 Aug 27;2(7461):475-6 PMID: 4161595
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Activity of steroid sulfatase in fibroblasts with numerical and structural X chromosome aberrations.
Hum Genet. 1981;57(4):354-6 PMID: 6945285
Structural anomalies of the X chromosome: personal observation and review of non-mosaic cases.
Clin Genet. 1982 Feb;21(2):145-59 PMID: 7044622
Genetic homology and crossing over in the X and Y chromosomes of Mammals.
Hum Genet. 1982;61(2):85-90 PMID: 7129448
Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factor.
Nature. 1982 Dec 2;300(5891):443-5 PMID: 6890629
Evidence for a dosage effect at the X-linked steroid sulfatase locus in human tissues.
Am J Hum Genet. 1983 Mar;35(2):234-40 PMID: 6573129
Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice.
Genetics. 1983 Jan;103(1):137-41 PMID: 6573292
The cell surface antigen locus, MIC2X, escapes X-inactivation.
Am J Hum Genet. 1984 Jul;36(4):777-82 PMID: 6540985
X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele.
Nature. 1985 May 16-22;315(6016):226-7 PMID: 3858674
Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal.
Nature. 1985 Oct 24-30;317(6039):687-92 PMID: 2997619
Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes.
Nature. 1985 Oct 24-30;317(6039):692-7 PMID: 2997620
A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.
Nature. 1986 Jan 23-29;319(6051):291-5 PMID: 3941746
Dosage of the Sts gene in the mouse.
Am J Hum Genet. 1986 Oct;39(4):470-6 PMID: 3464202
Chiasma distribution at diakinesis in the normal human male.
Hereditas. 1974;76(1):55-78 PMID: 4136005

Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/116.3.465

Published

1987-07-00

Pages

465-8

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1203157

Subset

External Links

PubMed source DOI: 10.1093/genetics/116.3.465 PMC Full Text View journal details

Analysis Services

Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse.

Contact

WeChat Official Account