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PMID: 6540985 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The cell surface antigen locus, MIC2X, escapes X-inactivation.

American journal of human genetics ·Vol. 36 ·No. 4 ·1984-07-00 ·Pages 777-82

Goodfellow P, Pym B, Mohandas T, Shapiro LJ

Abstract

Recently, it was shown that the cell surface antigen defined by the monoclonal antibody 12E7 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively. It was also shown that MIC2X is located in the region Xp22.3----Xpter and MIC2Y is in the region Ypter-Yq1.1. Here, we show that MIC2X escapes X-inactivation on structurally normal and abnormal inactive human X chromosomes.

MeSH Terms
Animals Antibodies, Monoclonal Antigens, Surface/genetics Chromosome Mapping Cloning, Molecular Cricetinae Dosage Compensation, Genetic Female Humans Hybrid Cells Male Mice Radioimmunoassay X Chromosome Y Chromosome
Chemicals
Antibodies, Monoclonal Antigens, Surface
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Goodfellow P
Pym B
Mohandas T
Shapiro L J
References (27)
27 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1984-07-00
Pages
777-82
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684497
Subset
IM
Grants
NICHD NIH HHS · HD-12178 · United States
NICHD NIH HHS · HD-15193 · United States
External Links
PubMed source PMC Full Text View journal details
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