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PMID: 3457380 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 7 ·1986-04-00 ·Pages 2157-61

Schimke RT, Sherwood SW, Hill AB, Johnston RN

Abstract

We propose that a fundamental problem in the faithful replication of complex chromosomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replication patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangements, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.

MeSH Terms
Aging Biological Evolution Cell Cycle Cell Physiological Phenomena Chromosome Aberrations DNA Replication Eukaryotic Cells/physiology Extrachromosomal Inheritance Gene Amplification Neoplasms/genetics Recombination, Genetic Sister Chromatid Exchange
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schimke R T
Sherwood S W
Hill A B
Johnston R N
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.7.2157
Published
1986-04-00
Pages
2157-61
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323250
Subset
IM
Grants
NCI NIH HHS · CA 16318 · United States
NIGMS NIH HHS · GM 14931 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.7.2157 PMC Full Text View journal details
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