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PMID: 3422745 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A gene activated by growth factors is related to the oncogene v-jun.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 5 ·1988-03-00 ·Pages 1487-91

Ryder K, Lau LF, Nathans D

Abstract

We have recently identified by cDNA cloning a set of genes that are rapidly activated in cultured mouse cells by protein growth factors. Here we report that the nucleotide sequence of a cDNA (clone 465) derived from one of these immediate early genes (hereafter called jun-B) encodes a protein homologous to that encoded by the avian sarcoma virus 17 oncogene v-jun. Homology between the jun-B and v-jun proteins is in two regions: one near the N terminus and the other at the C terminus. The latter sequence was shown by Vogt et al. [Vogt, P. K., Bos, T. J. & Doolittle, R. F. (1987) Proc. Natl. Acad. Sci. USA 84, 3316-3319] to have regions of sequence similarity to the DNA-binding domain of the yeast transcriptional regulatory protein GCN4 and to the oncogenic protein fos. Southern blots of human, mouse, and chicken DNA demonstrate that jun-B and c-jun are different genes and that there may be other vertebrate genes related to jun-B and c-jun. These findings suggest that there is a jun family of genes encoding related transcriptional regulatory proteins. The jun-B protein, and perhaps other members of the jun family, may play a role in regulating the genomic response to growth factors.

MeSH Terms
Amino Acid Sequence Base Sequence DNA-Binding Proteins/genetics Gene Expression Regulation Growth Substances/physiology Molecular Sequence Data Proto-Oncogenes Sequence Homology, Nucleic Acid Transcription Factors/genetics
Chemicals
DNA-Binding Proteins Growth Substances Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ryder K
Howard Hughes Medical Institute Laboratory, Baltimore, MD.
Lau L F
Nathans D
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38 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.5.1487
Published
1988-03-00
Pages
1487-91
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC279796
Subset
IM
Grants
NCI NIH HHS · 5 P01 CA16519 · United States
Databases
GENBANK
J03236
External Links
PubMed source DOI: 10.1073/pnas.85.5.1487 PMC Full Text View journal details
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