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PMID: 340929 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Synthesis and turnover of ribosomal proteins in the absence of 60S subunit assembly in Saccharomyces cerevisiae.

Molecular & general genetics : MGG ·Vol. 157 ·No. 3 ·1977-12-09 ·Pages 327-32

Gorenstein C, Warner JR

Abstract

We have measured the synthesis and stability of ribosomal proteins in a temperature sensitive strain of yeast which at the restrictive temperature is specifically blocked in the processing of 27S ribosomal precursor RNA. We find that in the absence of 60S ribosomal subunit assembly, the synthesis of all the ribosomal proteins studied continued. However, the proteins of the 60S subunit fail to accumulate and are rapidly degraded.

MeSH Terms
Electrophoresis, Polyacrylamide Gel Mutation Protein Precursors/metabolism RNA, Ribosomal/metabolism Ribosomal Proteins/metabolism Saccharomyces cerevisiae/metabolism
Chemicals
Protein Precursors RNA, Ribosomal Ribosomal Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gorenstein C
Warner J R
References (20)
20 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00268670
Published
1977-12-09
Pages
327-32
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00268670
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