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PMID: 3404583 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Thymidylate synthase gene of herpesvirus ateles.

Journal of virology ·Vol. 62 ·No. 9 ·1988-09-00 ·Pages 3530-5

Richter J, Puchtler I, Fleckenstein B

Abstract

The putative thymidylate synthase (TS) gene of herpesvirus ateles, a T-lymphotropic tumor virus of New World primates, has a single large open reading frame encoding a polypeptide of 32.9 kilodaltons. The gene is transcribed into an unspliced 2.4-kilobase mRNA that is abundantly expressed late in virus replication. The AT-rich 5' untranslated leader sequence of TS mRNA in herpesvirus ateles-infected cells is remarkable in length (1,184 nucleotides), containing 29 minicistrons; this may indicate a role in translation regulation.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Genes, Viral Herpesviridae/enzymology,genetics,physiology Molecular Sequence Data Protein Biosynthesis Protein Sorting Signals/genetics RNA, Messenger/genetics RNA, Viral/genetics Thymidylate Synthase/genetics Transcription, Genetic Virus Replication
Chemicals
Protein Sorting Signals RNA, Messenger RNA, Viral Thymidylate Synthase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Richter J
Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Puchtler I
Fleckenstein B
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.9.3530-3535.1988
Published
1988-09-00
Pages
3530-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253484
Subset
IM
Databases
GENBANK
M22036
External Links
PubMed source DOI: 10.1128/JVI.62.9.3530-3535.1988 PMC Full Text View journal details
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