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PMID: 332632 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Development of of macrophage migration inhibition in rabbits infected with virulent Treponema pallidum.

Infection and immunity ·Vol. 17 ·No. 3 ·1977-09-00 ·Pages 651-4

Pavia CS, Folds JD, Baseman JB

Abstract

Peritoneal exudate cells from rabbits infected with Treponema pallidum Nichols were used as indicators of macrophage migration inhibitory factor activity. Between 3 and 15 weeks after infection, the migration of peritoneal exudate cells was inhibited in the presence of 3 to 25 microgram of T. phagedenis biovar Reiter protein per ml. Before this period, the migration patterns of peritoneal exudate cells from infected animals were uninhibited and similar to those from noninfected control rabbits. These observations were correlated with the development of active cell-mediated immunity during experimental T. pallidum infection.

MeSH Terms
Animals Antigens, Bacterial Cell Migration Inhibition Dose-Response Relationship, Immunologic Macrophage Migration-Inhibitory Factors/biosynthesis Macrophages/microbiology Male Rabbits Syphilis/microbiology Treponema pallidum/immunology,pathogenicity
Chemicals
Antigens, Bacterial Macrophage Migration-Inhibitory Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pavia C S
Folds J D
Baseman J B
References (17)
17 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.17.3.651-654.1977
Published
1977-09-00
Pages
651-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421177
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.17.3.651-654.1977 PMC Full Text View journal details
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