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PMID: 1156847 Published · ppublish English Journal Article

Cell response in rabbits infected with T. pallidum as measured by the leucocyte migration inhibition test.

The British journal of venereal diseases ·Vol. 51 ·No. 4 ·1975-08-00 ·Pages 240-5

Wicher V, Wicher K

Abstract

Leucocyte migration in agarose was used to examine cell response in 48 rabbits infected with the Nichols strain of T. pallidum for 1 week to 16 months. The response of the peripheral leucocytes to T. pallidum antigen (TpAg), 3 and 15 mug/ml., Reiter antigen (RAg) 6 mug./ml., and VDRL reagent 1:500 was examined. The cells in the presence of RAg, TpAg--3 mug./ml.--and the VDRL reagent demonstrated a biphasic response; in the early stage of infection (until the 4th week) stimulation of leucocyte migration and in the later stage of disease inhibition of leucocyte migration was observed. The higher concentration of TpAg--15 mug./ml.--caused only inhibition of leucocyte migration. The leucocyte response in vitro could not be confirmed by intradermal skin tests with 5 x 10(7) heat-killed T. pallidum. No correlation between the cell response and the treponemal antibodies was observed.

MeSH Terms
Animals Antibody Formation Cell Migration Inhibition Immunity, Cellular Male Rabbits Skin Tests Syphilis/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wicher V
Wicher K
References (20)
20 references, click to expand
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Article Info
Journal
The British journal of venereal diseases
Abbr.
Br J Vener Dis
ISSN
0007-134X
DOI
10.1136/sti.51.4.240
Published
1975-08-00
Pages
240-5
Language
English
Region
England
NLM ID
0421042
PMCID
PMC1046557
Subset
IM
External Links
PubMed source DOI: 10.1136/sti.51.4.240 PMC Full Text
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