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PMID: 3323846 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The Escherichia coli cell division proteins FtsY, FtsE and FtsX are inner membrane-associated.

Molecular & general genetics : MGG ·Vol. 210 ·No. 3 ·1987-12-00 ·Pages 504-8

Gill DR, Salmond GP

Abstract

The cell division genes ftsY, ftsE and ftsX form an operon mapping at 76 min on the Escherichia coli chromosome. The protein products of these genes have been identified previously. We have studied the cellular location of the radiolabelled Fts proteins using maxicells and standard fractionation procedures. Previous protein sequence homologies suggested an inner membrane location for FtsE. We have confirmed this predicted location and have shown that FtsY and FtsX are also inner membrane-associated. These results are in agreement with the hypothesis that FtsE may act at the inner membrane, in a "septalsome" complex, by coupling ATP hydrolysis to the process of bacterial cell division.

MeSH Terms
Bacterial Proteins/metabolism Cell Compartmentation Cell Division Cell Fractionation Cell Membrane/metabolism Escherichia coli/ultrastructure Genes, Bacterial Magnesium/metabolism Molecular Weight
Chemicals
Bacterial Proteins Magnesium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gill D R
Biological Sciences, University of Warwick, Coventry, UK.
Salmond G P
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00327204
Published
1987-12-00
Pages
504-8
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00327204
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