The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.

The Journal of experimental medicine ·Vol. 149 ·No. 1 ·1979-01-01 ·Pages 137-49

Prud'homme GJ, Sohn U, Delovitch TL

Abstract

By using an indirect immunofluorescence technique, the presence of host cell derived H-2K, H-2D, and Ia alloantigens on donor cells recovered from recipient spleens after a graft-versus-host response (GVHR) was demonstrated. Mapping studies indicated that only host K, D, and I-A region gene products could be identified on the donor cells. Host I-E/C- and I-J-subregion products were not absorbed by donor cells. Treatment of activated donor cells with anti-Ly sera plus C' revealed that donor cells carrying host Ia antigens have a Ly-1+,2-,3- phenotype, whereas donor cells carrying H-2K and H-2D host antigens have a Ly-1-,2+,3+ phenotype. A GVHR that resulted from only an I-region incompatibility was suppressed by the injection of recipient mice with an anti-Ia antiserum directed against self Ia antigens. The degree of suppression was proportional to the amount of anti-Ia antiserum administered.

MeSH Terms

Animals Antigens, Surface Graft vs Host Reaction H-2 Antigens/genetics Immunosuppression Therapy Isoantibodies Isoantigens/genetics Major Histocompatibility Complex Mice T-Lymphocytes/immunology

Chemicals

Antigens, Surface H-2 Antigens Isoantibodies Isoantigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Prud'homme G J

Sohn U

Delovitch T L

References (31)

31 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.149.1.137

Published

1979-01-01

Pages

137-49

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2184751

Subset

External Links

PubMed source DOI: 10.1084/jem.149.1.137 PMC Full Text View journal details

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The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.

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