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PMID: 3295297 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages.

Journal of virology ·Vol. 61 ·No. 7 ·1987-07-00 ·Pages 2138-42

Biegalke BJ, Heaney ML, Bouton A, Parsons JT, Linial M

Abstract

A number of MC29 mutants with deleted myc genes have been previously characterized. Many of these mutants have been found to be defective for transformation of chicken macrophages in vitro and for tumor induction in chickens. Such mutants are capable of transforming Japanese quail macrophages in vitro and inducing a high incidence of tumors in Japanese quail. Thus, Japanese quail may contain a factor(s) capable of complementing the defective transforming proteins encoded by some deleted v-myc genes.

MeSH Terms
Animals Cell Transformation, Viral Cells, Cultured Chickens/microbiology Coturnix/microbiology DNA, Neoplasm/analysis Defective Viruses/genetics,physiology Fibroblasts/microbiology Macrophages/microbiology Mutation Neoplasms, Experimental/etiology,genetics Oncogene Protein p55(v-myc) Quail/microbiology Retroviridae Proteins/genetics Species Specificity
Chemicals
DNA, Neoplasm Oncogene Protein p55(v-myc) Retroviridae Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Biegalke B J
Heaney M L
Bouton A
Parsons J T
Linial M
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22 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.7.2138-2142.1987
Published
1987-07-00
Pages
2138-42
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254234
Subset
IM
Grants
NCI NIH HHS · CA 18282 · United States
NCI NIH HHS · CA 27578 · United States
NCI NIH HHS · CA 28151 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.7.2138-2142.1987 PMC Full Text View journal details
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