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PMID: 3293046 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transmitter and receiver modules in bacterial signaling proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 14 ·1988-07-00 ·Pages 4981-5

Kofoid EC, Parkinson JS

Abstract

Prokaryotes are capable of sophisticated sensory behaviors. We have detected sequence motifs in bacterial signaling proteins that may act as transmitter or receiver modules in mediating protein-protein communication. These modules appear to retain their functional identities in many protein hosts, implying that they are structurally independent elements. We propose that the fundamental activity characterizing these domains is specific recognition and association of matched modules, accompanied by conformational changes in one or both of the interacting elements. Signal propagation is a natural consequence of this behavior. The versatility of this information-processing strategy is evident in the chemotaxis machinery of Escherichia coli, where proteins containing transmitters or receivers are linked in "dyadic relays" to form complex signaling networks.

MeSH Terms
Amino Acid Sequence Bacterial Proteins/genetics,physiology Biological Evolution Chemotaxis Escherichia coli/physiology Gene Expression Regulation Molecular Sequence Data Transcription Factors/physiology
Chemicals
Bacterial Proteins Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kofoid E C
Biology Department, University of Utah, Salt Lake City 84112.
Parkinson J S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.14.4981
Published
1988-07-00
Pages
4981-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC281671
Subset
IM
Grants
NIGMS NIH HHS · GM19559 · United States
NIGMS NIH HHS · GM28706 · United States
External Links
PubMed source DOI: 10.1073/pnas.85.14.4981 PMC Full Text View journal details
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