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PMID: 327016 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.

The Journal of experimental medicine ·Vol. 146 ·No. 2 ·1977-08-01 ·Pages 520-34

Genovesi EV, Marx PA, Wheelock EF

Abstract

Friend leukemia virus (FLV) erythroleukemic cells cultured in medium containing FLV-immune serum from dormant FLV-infected mice undergo modulation of FLV cell surface antigens. Modulation was determined by an increased resistance to FLV antibody-mediated complement-dependent lysis and was associated temporally with the capping of FLV-immune complexes at the cell surface. Modulated cells regained their susceptibility to FLV antibody-mediated complement-dependent lysis when transferred to medium containing normal mouse serum. After 48 h of culture in FLV-immune serum, 26% of the FLV erythroleukemic cells were devoid of FLV cell surface antigens as demonstrated by immunofluoresence. Antigenic modulation occurred to a greater extent in cells maintained in logarithmic growth than in cells in GO or resting phase. FLV-antigenic modulation is discussed as a possible mechanism by which antibody induces and maintains FLV-transformed cells in a dormant state.

MeSH Terms
Animals Antigen-Antibody Complex Antigens, Viral/analysis Cell Line Clone Cells Cytotoxicity Tests, Immunologic Female Fluorescent Antibody Technique Friend murine leukemia virus/immunology Immune Sera/pharmacology Immunoglobulin G/analysis In Vitro Techniques Kinetics Leukemia, Erythroblastic, Acute/immunology Mice Mice, Inbred DBA/immunology Tumor Virus Infections/immunology
Chemicals
Antigen-Antibody Complex Antigens, Viral Immune Sera Immunoglobulin G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Genovesi E V
Marx P A
Wheelock E F
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39 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.146.2.520
Published
1977-08-01
Pages
520-34
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180763
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.146.2.520 PMC Full Text View journal details
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