Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 2 ·1976-02-00 ·Pages 620-4

Huebner RJ, Gilden RV, Lane WT, Toni R, Trimmer RW, Hill PR

Abstract

Immunization of crossbred and F1 mice with combined killed and live Gross leukemia virus AKR type-C viral vaccines suppressed endogeneous N-type AKR virus up to 10,000-fold for significant periods during early life. Since several previous studies in the same and similar crossbred systems revealed direct correlations between low and high levels of type-C virus early in life with low and high incidences of leukemia and other cancers later in life, we believe that prospects for suppression of spontaneous neoplasms are good; however, 8-14 months will be required to achieve the final results. Should cancers be prevented by serotype-specific vaccines, such evidence would provide conclusive proof of endogenous viral etiology.

MeSH Terms

AKR murine leukemia virus/immunology Age Factors Animals Antigen-Antibody Reactions Genes Mice Neoplasms, Experimental/prevention & control Retroviridae/growth & development,immunology Vaccination

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Huebner R J

Gilden R V

Lane W T

Toni R

Trimmer R W

Hill P R

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26 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.2.620

Published

1976-02-00

Pages

620-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC335963

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.2.620 PMC Full Text View journal details

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Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.

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