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PMID: 3264791 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus.

Experimental brain research ·Vol. 73 ·No. 1 ·1988-00-00 ·Pages 15-22

Date I, Kawamura K, Nakashima H

Abstract

Using an immunocytochemical method, we examined the immunological responses of adult mice to intracerebellar syngeneic and allogeneic fetal mouse brainstem transplants (embryonic days 12-14). Syngeneic grafts and major histocompatibility complex (MHC)-compatible and non-MHC-incompatible allogeneic grafts survived well, showing no histological signs of rejection even 6 months after transplantation, and with no expression of MHC antigens being observed in any of the grafts. However, most cases of both MHC- and non-MHC-incompatible allografts showed rejection responses, such as marked neovascularization, cellular infiltration and necrosis, two weeks to one month after transplantation. In animals showing rejection, Class I MHC antigens were found on grafted neuronal tissue. An increased number of reactive astrocytes was also observed in the grafts. High levels of Class I antigen expression and prominent gliosis correlated with vigorous cellular infiltration. A quantitative analysis of T cell subsets in the animals showing rejection revealed that the L3T4/Lyt-2 ratio was 1.02 +/- 0.21 (mean +/- S.D.), indicating that helper/inducer and cytotoxic/suppressor T cells appeared equally in the rejection of MHC- and non-MHC-incompatible allografts. We consider that in these experiments, the brain was not completely an immunologically privileged site, and that MHC- and non-MHC-incompatible intraparenchymal neural transplants were not shielded from host immune surveillance.

MeSH Terms
Animals Brain Stem/immunology,transplantation Cerebellum/immunology,pathology Graft Rejection Major Histocompatibility Complex/immunology Mice Mice, Inbred BALB C Mice, Inbred C3H Neuroglia/pathology T-Lymphocytes/pathology Transplantation, Homologous Transplantation, Isogeneic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Date I
Department of Neurological Surgery, Okayama University Medical School, Japan.
Kawamura K
Nakashima H
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00279656
Published
1988-00-00
Pages
15-22
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00279656 View journal details
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