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PMID: 3263088 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tumour necrosis factor in synovial exudates.

Annals of the rheumatic diseases ·Vol. 47 ·No. 9 ·1988-09-00 ·Pages 768-72

Di Giovine FS, Nuki G, Duff GW

Abstract

The actions of tumour necrosis factor (TNF) include resorption of bone and cartilage, suggesting a potential role in the pathogenesis of arthritis. TNF activity was looked for in synovial fluids from 137 patients with different rheumatic diseases. Unfractionated samples were tested in the L929 bioassay. Significant TNF activity that was neutralised by monoclonal antibody to TNF alpha occurred in 13 (30%) of 44 samples. Raised TNF levels were not associated with any particular disease type or routine laboratory markers of inflammation but were related to disease duration in osteoarthritis. The finding of biologically active TNF in symptomatic joints of arthritic patients supports the idea that it may contribute to the pathogenesis of joint damage in chronic rheumatic diseases.

MeSH Terms
Biological Assay Humans Knee Joint Rheumatic Diseases/metabolism Synovial Fluid/analysis Tumor Necrosis Factor-alpha/analysis
Chemicals
Tumor Necrosis Factor-alpha
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Di Giovine F S
University of Edinburgh Department of Medicine, UK.
Nuki G
Duff G W
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29 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.47.9.768
Published
1988-09-00
Pages
768-72
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1003595
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.47.9.768 PMC Full Text View journal details
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