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PMID: 3258568 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nasopharyngeal carriage and antibiotic resistance of Haemophilus influenzae in healthy children.

Epidemiology and infection ·Vol. 100 ·No. 2 ·1988-04-00 ·Pages 193-203

Howard AJ, Dunkin KT, Millar GW

Abstract

An investigation was undertaken to determine the isolation rate and antibiotic resistance of Haemophilus influenzae from the nasopharynx of young children. The 996 subjects studied were up to 6 years of age. H. influenzae was isolated from 304 (30.5%) and strains of capsular type b from 11 (1.1%). Age, sibling status, season, respiratory infection and antibiotic therapy all influenced isolation rates. The overall prevalence of antibiotic resistance in the strains isolated was ampicillin 5.4% (all beta-lactamase producers), cefaclor 0.3%, chloramphenicol 1.3%, erythromycin 38.2%, tetracycline 1.3%, trimethoprim 5.4% and sulphamethoxazole 0%. Ampicillin resistance was more common in type b than non-capsulated strains.

MeSH Terms
Aging Anti-Bacterial Agents/pharmacology,therapeutic use Carrier State/epidemiology Child, Preschool Drug Resistance, Microbial Family Characteristics Female Haemophilus Infections/epidemiology Haemophilus influenzae/drug effects,growth & development,isolation & purification Humans Infant Infant, Newborn Male Nasopharynx/microbiology Respiratory Tract Infections/microbiology Seasons
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Howard A J
Gwynedd Hospital, Penrhosgarnedd, Gwynedd, N. Wales.
Dunkin K T
Millar G W
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33 references, click to expand
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Article Info
Journal
Epidemiology and infection
Abbr.
Epidemiol Infect
ISSN
0950-2688
DOI
10.1017/s0950268800067327
Published
1988-04-00
Pages
193-203
Language
English
Region
England
NLM ID
8703737
PMCID
PMC2249230
Subset
IM
External Links
PubMed source DOI: 10.1017/s0950268800067327 PMC Full Text View journal details
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