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PMID: 31501419 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of pyroptosis in cancer: pro-cancer or pro-"host"?

Cell death & disease ·Vol. 10 ·No. 9 ·2019-00-09 ·Pages 650

Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J, Hu J

Abstract

Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all mechanisms of PCD. Among these mechanisms, pyroptosis is mediated by the gasdermin family, accompanied by inflammatory and immune responses. The relationship between pyroptosis and cancer is complex, and the effects of pyroptosis on cancer vary in different tissues and genetic backgrounds. On one hand, pyroptosis can inhibit the occurrence and development of tumors; on the other hand, as a type of proinflammatory death, pyroptosis can form a suitable microenvironment for tumor cell growth and thus promote tumor growth. In addition, the induction of tumor pyroptosis is also considered a potential cancer treatment strategy. Studies have shown that DFNA5 (nonsyndromic hearing impairment protein 5)/GSDME (Gasdermin-E) mRNA methylation results in lower expression levels of DFNA5/GSDME in most tumor cells than in normal cells, making it difficult to activate the pyroptosis in most tumor cells. During the treatment of malignant tumors, appropriate chemotherapeutic drugs can be selected according to the expression levels of DFNA5/GSDME, which can be upregulated in tumor cells, thereby increasing the sensitivity to chemotherapeutic drugs and reducing drug resistance. Therefore, induced pyroptosis may play a predominant role in the treatment of cancer. Here, we review the latest research on the anti- and protumor effects of pyroptosis and its potential applications in cancer treatment.

MeSH Terms
Animals Apoptosis/genetics,physiology Hearing Loss, Sensorineural/genetics,metabolism Humans Pyroptosis/genetics,physiology RNA, Messenger/metabolism Receptors, Estrogen/genetics,metabolism
Chemicals
GSDME protein, human RNA, Messenger Receptors, Estrogen
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Xia Xiaojing ORCID
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China. quik500@163.com.
Wang Xin
College of Agriculture and Forestry Science, Linyi University, Linyi, China.
Cheng Zhe
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Qin Wanhai
Amsterdam UMC, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam Infection and Immunity, Meibergdreef 9, 1105AZ, Amsterdam, Netherlands.
Lei Liancheng
College of Veterinary Medicine, Jilin University, Changchun, China.
Jiang Jinqing
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Hu Jianhe
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Supplementary Concepts
Deafness, Autosomal Dominant 5 (Disease)
References (126)
126 references, click to expand
  1. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
    Science. 2018 Nov 23;362(6417):956-960 PMID: 30467171
  2. Interleukin-1β in innate inflammation, autophagy and immunity.
    Semin Immunol. 2013 Dec 15;25(6):416-24 PMID: 24275601
  3. NLRP3 inflammasome: Its regulation and involvement in atherosclerosis.
    J Cell Physiol. 2018 Mar;233(3):2116-2132 PMID: 28345767
  4. Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis.
    Int J Biol Sci. 2018 Mar 10;14(4):406-417 PMID: 29725262
  5. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
    Nat Med. 2018 Aug;24(8):1151-1156 PMID: 29967349
  6. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Sci Rep. 2015 Nov 10;5:16222 PMID: 26552848
  7. Pro-inflammatory programmed cell death.
    Trends Microbiol. 2001 Mar;9(3):113-4 PMID: 11303500
  8. The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection.
    Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):1-10 PMID: 31059737
  9. Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.
    Eur J Biochem. 1998 Feb 15;252(1):169-77 PMID: 9523727
  10. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
    Nat Immunol. 2010 Dec;11(12):1136-42 PMID: 21057511
  11. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.
    Immunol Rev. 2017 May;277(1):61-75 PMID: 28462526
  12. Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
    Breast Cancer Res Treat. 2010 Aug;122(3):699-710 PMID: 19859801
  13. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
    Nature. 2017 Jul 6;547(7661):99-103 PMID: 28459430
  14. Beneficial and Detrimental Roles of NLRs in Carcinogenesis.
    Front Immunol. 2013 Nov 12;4:370 PMID: 24273542
  15. Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.
    Cancer Sci. 2007 Jan;98(1):88-95 PMID: 17083569
  16. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells.
    Infect Immun. 2005 Apr;73(4):1907-16 PMID: 15784530
  17. Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis.
    PLoS Pathog. 2007 Nov;3(11):e161 PMID: 17983266
  18. A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch.
    Apoptosis. 2019 Feb;24(1-2):74-82 PMID: 30519834
  19. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
    Nat Commun. 2014;5:3209 PMID: 24492532
  20. Gasdermin-B promotes invasion and metastasis in breast cancer cells.
    PLoS One. 2014 Mar 27;9(3):e90099 PMID: 24675552
  21. The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages.
    Infect Immun. 1997 Dec;65(12):5165-70 PMID: 9393811
  22. [Pyroptosis induced by zinc oxide nanoparticles in A549 cells].
    Wei Sheng Yan Jiu. 2013 Mar;42(2):273-6 PMID: 23654106
  23. Inflammatory caspases are innate immune receptors for intracellular LPS.
    Nature. 2014 Oct 9;514(7521):187-92 PMID: 25119034
  24. Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach.
    Transl Oncol. 2019 Jul;12(7):925-931 PMID: 31085408
  25. Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
    Int J Cancer. 2000 Nov 15;88(4):535-46 PMID: 11058868
  26. Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins.
    J Dig Dis. 2018 Feb;19(2):74-83 PMID: 29314754
  27. The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.
    EMBO Mol Med. 2014 Aug 20;6(10):1263-78 PMID: 25143352
  28. Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.
    J Mol Biol. 2018 Sep 14;430(18 Pt B):3068-3080 PMID: 29990470
  29. The HSV-2 mutant DeltaPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins.
    Gene Ther. 2010 Mar;17(3):315-27 PMID: 19798049
  30. Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer.
    Oncol Rep. 2018 Nov;40(5):2648-2658 PMID: 30226619
  31. A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma.
    EBioMedicine. 2019 Mar;41:244-255 PMID: 30876762
  32. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases.
    Immunity. 2010 Mar 26;32(3):367-78 PMID: 20226691
  33. ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
    Sci Rep. 2018 Feb 28;8(1):3788 PMID: 29491424
  34. Complex roles of inflammasomes in carcinogenesis.
    Cancer J. 2013 Nov-Dec;19(6):468-72 PMID: 24270345
  35. Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer.
    Oncol Rep. 2018 Oct;40(4):1971-1984 PMID: 30106450
  36. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.
    Proc Natl Acad Sci U S A. 2014 May 20;111(20):7403-8 PMID: 24803432
  37. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis.
    Cell Res. 2016 Sep;26(9):1007-20 PMID: 27573174
  38. Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer.
    Clin Epigenetics. 2018 Apr 11;10:51 PMID: 29682089
  39. Design and optimize N-substituted EF24 as effective and low toxicity NF-κB inhibitor for lung cancer therapy via apoptosis-to-pyroptosis switch.
    Chem Biol Drug Des. 2019 Jul;94(1):1368-1377 PMID: 30873716
  40. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.
    Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21635-40 PMID: 21118981
  41. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
    Nature. 2016 Jul 06;535(7610):153-8 PMID: 27383986
  42. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
    Cell Res. 2018 Dec;28(12):1171-1185 PMID: 30287942
  43. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.
    Genes Chromosomes Cancer. 2009 Mar;48(3):261-71 PMID: 19051310
  44. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
    Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897 PMID: 30381458
  45. Pyroptosis: host cell death and inflammation.
    Nat Rev Microbiol. 2009 Feb;7(2):99-109 PMID: 19148178
  46. The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis.
    J Immunol. 2015 Apr 1;194(7):3369-80 PMID: 25725098
  47. FcγRI (CD64) contributes to the severity of immune inflammation through regulating NF-κB/NLRP3 inflammasome pathway.
    Life Sci. 2018 Aug 15;207:296-303 PMID: 29920250
  48. DAC can restore expression of NALP1 to suppress tumor growth in colon cancer.
    Cell Death Dis. 2015 Jan 22;6:e1602 PMID: 25611377
  49. The expression and regulation of DFNA5 in human hepatocellular carcinoma DFNA5 in hepatocellular carcinoma.
    Mol Biol Rep. 2013 Dec;40(12):6525-31 PMID: 24154762
  50. Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma.
    Oncotarget. 2016 Dec 20;7(51):84658-84665 PMID: 27705930
  51. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
    Science. 2018 Nov 30;362(6418):1064-1069 PMID: 30361383
  52. Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment.
    J Cancer Prev. 2017 Jun;22(2):62-73 PMID: 28698859
  53. Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.
    Trends Biochem Sci. 2017 Apr;42(4):245-254 PMID: 27932073
  54. Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.
    Cell Rep. 2018 Mar 13;22(11):2924-2936 PMID: 29539421
  55. Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression: apoptosis, necroptosis, and pyroptosis.
    J Virol. 2012 Oct;86(20):10961-78 PMID: 22837196
  56. Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells.
    Jpn J Cancer Res. 2001 Feb;92(2):140-51 PMID: 11223543
  57. Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer.
    Cancer Med. 2019 May;8(5):2133-2145 PMID: 30993897
  58. Caspase substrates.
    Cell Death Differ. 2007 Jan;14(1):66-72 PMID: 17082814
  59. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells.
    Mamm Genome. 2000 Sep;11(9):718-24 PMID: 10967128
  60. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.
    Cell. 1998 Feb 20;92(4):501-9 PMID: 9491891
  61. Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma.
    Phytomedicine. 2019 Mar 15;56:286-294 PMID: 30668350
  62. Salmonella-induced cell death: apoptosis, necrosis or programmed cell death?
    Trends Microbiol. 2001 Feb;9(2):64-7 PMID: 11173244
  63. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
    J Exp Med. 2010 May 10;207(5):1045-56 PMID: 20385749
  64. Inflammatory stimuli regulate caspase substrate profiles.
    Mol Cell Proteomics. 2010 May;9(5):880-93 PMID: 20173201
  65. Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis.
    Cancer Lett. 2019 May 28;450:22-31 PMID: 30771436
  66. GSDME as an executioner of chemotherapy-induced cell death.
    Sci China Life Sci. 2017 Nov;60(11):1291-1294 PMID: 29134415
  67. Pyroptosis of MCF7 Cells Induced by the Secreted Factors of hUCMSCs.
    Stem Cells Int. 2018 Nov 11;2018:5912194 PMID: 30534157
  68. Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation.
    Apoptosis. 2019 Apr;24(3-4):312-325 PMID: 30710195
  69. Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells.
    Cell Death Differ. 2014 Dec;21(12):1914-24 PMID: 25124554
  70. GSDMD is required for effector CD8+ T cell responses to lung cancer cells.
    Int Immunopharmacol. 2019 Sep;74:105713 PMID: 31276977
  71. Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer.
    Biochem Biophys Res Commun. 2008 May 23;370(1):38-43 PMID: 18346456
  72. Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway.
    Oncotarget. 2016 Jun 14;7(24):36185-36197 PMID: 27167192
  73. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
    Nat Chem Biol. 2017 Jan;13(1):46-53 PMID: 27820798
  74. Shigella flexneri induces apoptosis in infected macrophages.
    Nature. 1992 Jul 9;358(6382):167-9 PMID: 1614548
  75. Brucella evasion of adaptive immunity.
    Future Microbiol. 2013 Feb;8(2):147-54 PMID: 23374122
  76. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis.
    J Exp Med. 2005 Oct 17;202(8):1043-9 PMID: 16230474
  77. LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation.
    Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):913-923 PMID: 30922944
  78. Inflammasomes in cancer: a double-edged sword.
    Protein Cell. 2014 Jan;5(1):12-20 PMID: 24474192
  79. The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.
    J Hum Genet. 2006;51(8):652-664 PMID: 16897187
  80. IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation.
    Mol Cancer. 2012 Nov 23;11:87 PMID: 23174018
  81. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages.
    Cell Microbiol. 2006 Nov;8(11):1812-25 PMID: 16824040
  82. Pyroptotic cell death defends against intracellular pathogens.
    Immunol Rev. 2015 May;265(1):130-42 PMID: 25879289
  83. Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells.
    Sci Rep. 2018 Jan 31;8(1):1952 PMID: 29386662
  84. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
    Nature. 2015 Oct 29;526(7575):666-71 PMID: 26375259
  85. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression.
    Lab Invest. 2014 Jan;94(1):52-62 PMID: 24166187
  86. Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
    Cell Mol Life Sci. 2017 Jul;74(13):2395-2411 PMID: 28224203
  87. Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense.
    Oncogene. 2018 Sep;37(38):5191-5204 PMID: 29844574
  88. Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro.
    Acta Pharmacol Sin. 2019 Sep;40(9):1237-1244 PMID: 30914761
  89. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis.
    Oncogene. 2019 Apr;38(14):2658-2674 PMID: 30538296
  90. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
    Nature. 2014 Jan 23;505(7484):509-14 PMID: 24356306
  91. Targeting apoptosis for anticancer therapy.
    Semin Cancer Biol. 2015 Apr;31:84-8 PMID: 24859747
  92. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells.
    Cell Death Dis. 2019 Feb 25;10(3):193 PMID: 30804337
  93. Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.
    PLoS One. 2016 Nov 11;11(11):e0166422 PMID: 27835699
  94. Caspase substrates and cellular remodeling.
    Annu Rev Biochem. 2011;80:1055-87 PMID: 21456965
  95. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.
    Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7858-63 PMID: 27339137
  96. Mechanisms and functions of inflammasomes.
    Cell. 2014 May 22;157(5):1013-22 PMID: 24855941
  97. Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death.
    Clin Cancer Res. 2018 Dec 1;24(23):6066-6077 PMID: 30061362
  98. Non-canonical inflammasome activation targets caspase-11.
    Nature. 2011 Oct 16;479(7371):117-21 PMID: 22002608
  99. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
    Nature. 2015 Oct 29;526(7575):660-5 PMID: 26375003
  100. Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues.
    Pathology. 2008 Jan;40(1):13-24 PMID: 18038310
  101. Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
    Cancer Res. 2018 Nov 1;78(21):6183-6195 PMID: 30224377
  102. Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients.
    Int J Cancer. 2014 Nov 15;135(10):2387-96 PMID: 24729378
  103. Pore-forming activity and structural autoinhibition of the gasdermin family.
    Nature. 2016 Jul 7;535(7610):111-6 PMID: 27281216
  104. MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis.
    Mol Cancer Res. 2019 Jun;17(6):1316-1325 PMID: 30796177
  105. DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells.
    FEBS Lett. 2001 Apr 6;494(1-2):54-9 PMID: 11297734
  106. Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB).
    Genes Genet Syst. 2010 Feb;85(1):75-83 PMID: 20410667
  107. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.
    Nat Commun. 2017 Jan 03;8:14128 PMID: 28045099
  108. Diverging inflammasome signals in tumorigenesis and potential targeting.
    Nat Rev Cancer. 2019 Apr;19(4):197-214 PMID: 30842595
  109. NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells.
    Cell Mol Gastroenterol Hepatol. 2016 Mar 19;2(4):439-453 PMID: 27777967
  110. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
    Science. 2016 Nov 11;354(6313):765-768 PMID: 27846608
  111. Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma.
    Oncogene. 2008 Jun 5;27(25):3624-34 PMID: 18223688
  112. The Nlrp3 inflammasome: contributions to intestinal homeostasis.
    Trends Immunol. 2011 Apr;32(4):171-9 PMID: 21388882
  113. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
    J Cell Biol. 2000 May 1;149(3):613-22 PMID: 10791975
  114. Euxanthone exhibits anti-proliferative and anti-invasive activities in hepatocellular carcinoma by inducing pyroptosis: preliminary results.
    Eur Rev Med Pharmacol Sci. 2018 Dec;22(23):8186-8196 PMID: 30556857
  115. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
    Cell Death Differ. 2018 Mar;25(3):486-541 PMID: 29362479
  116. miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis.
    Oncol Res. 2017 Jul 5;25(6):1009-1019 PMID: 28244850
  117. Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation.
    Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4857-66 PMID: 27482109
  118. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1.
    Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2396-401 PMID: 10051653
  119. Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
    Cell Rep. 2019 Jun 18;27(12):3646-3656.e5 PMID: 31216481
  120. E2-Induced Activation of the NLRP3 Inflammasome Triggers Pyroptosis and Inhibits Autophagy in HCC Cells.
    Oncol Res. 2019 Jul 12;27(7):827-834 PMID: 30940293
  121. 'Hints' in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death.
    Cell Death Differ. 2017 Apr;24(4):588-596 PMID: 28362726
  122. GSDME mediates caspase-3-dependent pyroptosis in gastric cancer.
    Biochem Biophys Res Commun. 2018 Jan 1;495(1):1418-1425 PMID: 29183726
  123. Salmonella typhimurium invasion induces apoptosis in infected macrophages.
    Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9833-8 PMID: 8790417
  124. Analysis of the Cancer Genome Atlas Data Reveals Novel Putative ncRNAs Targets in Hepatocellular Carcinoma.
    Biomed Res Int. 2018 Jun 26;2018:2864120 PMID: 30046591
  125. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
    J Exp Med. 2017 May 1;214(5):1351-1370 PMID: 28404595
  126. Inflammasomes as molecular mediators of inflammation and cancer: potential role in melanoma.
    Cancer Lett. 2012 Jan 1;314(1):24-33 PMID: 22050907
Article Info
Journal
Cell death & disease
Abbr.
Cell Death Dis
ISSN
2041-4889
DOI
10.1038/s41419-019-1883-8
Email
quik500@163.com
Published
2019-00-09
Epub
2019-00-09
Pages
650
Language
English
Region
England
NLM ID
101524092
PMCID
PMC6733901
Subset
IM
External Links
PubMed source DOI: 10.1038/s41419-019-1883-8 PMC Full Text View journal details
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