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PMID: 3143572 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mechanisms of beta-lactam resistance in Haemophilus influenzae.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 7 ·No. 5 ·1988-10-00 ·Pages 610-5

Gutmann L, Williamson R, Collatz E, Acar JF

Abstract

Haemophilus influenzae has become increasingly resistant to beta-lactam antibiotics. Three major mechanisms, both enzymatic and non-enzymatic, are involved. Enzymatic resistance is mainly due to production of a TEM-1 plasmid-mediated beta-lactamase, and in some cases to a new enzyme ROB-1. Of the non-enzymatic mechanisms, decreased permeability due to alteration of outer membrane proteins seems to be rare in comparison to decreased affinity of penicillin-binding proteins for beta-lactam antibiotics. Enzymatic resistance is present in about 10-20% of clinical isolates, while non-enzymatic resistance is present only in 2-4%.

MeSH Terms
Anti-Bacterial Agents/metabolism,pharmacology Bacterial Proteins Carrier Proteins/metabolism Cell Membrane Permeability Drug Resistance, Microbial Haemophilus influenzae/drug effects,enzymology Hexosyltransferases Humans Muramoylpentapeptide Carboxypeptidase/metabolism Penicillin-Binding Proteins Peptidyl Transferases beta-Lactamases/metabolism beta-Lactams
Chemicals
Anti-Bacterial Agents Bacterial Proteins Carrier Proteins Penicillin-Binding Proteins beta-Lactams Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase beta-Lactamases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gutmann L
Laboratoire de Microbiologie Médicale, Hopital Saint-Joseph, Paris, France.
Williamson R
Collatz E
Acar J F
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Article Info
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Abbr.
Eur J Clin Microbiol Infect Dis
ISSN
0934-9723
DOI
10.1007/BF01964237
Published
1988-10-00
Pages
610-5
Language
English
Region
Germany
NLM ID
8804297
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01964237 View journal details
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