Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 5 ·1986-05-00 ·Pages 955-7

Gutmann L, Kitzis MD, Yamabe S, Acar JF

Abstract

YTR 830, a new beta-lactamase inhibitor, combined with amoxicillin or carbenicillin, showed a synergistic effect similar to that observed with clavulanic acid, and generally better than that with sulbactam, against strains harboring chromosome-encoded penicillinases and broad-spectrum beta-lactamases or plasmid-determined beta-lactamases. With ampicillin, YTR 830 showed the best synergistic activity of the inhibitors against Proteus morganii, Citrobacter freundii, and Enterobacter cloacae and their mutants with a derepressed chromosome-encoded cephalosporinase.

MeSH Terms

Anti-Bacterial Agents/pharmacology Bacteria/drug effects,enzymology Drug Interactions Microbial Sensitivity Tests Penicillanic Acid/pharmacology Plasmids Tazobactam beta-Lactamase Inhibitors

Chemicals

Anti-Bacterial Agents beta-Lactamase Inhibitors Penicillanic Acid Tazobactam

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Gutmann L

Kitzis M D

Yamabe S

Acar J F

References (6)

6 references, click to expand

The beta-lactamases of gram-negative bacteria and their possible physiological role.
Adv Microb Physiol. 1973;9:31-88 PMID: 4581138
Resistance to cephalosporins among gentamicin-resistant klebsiellae.
J Antimicrob Chemother. 1982 Apr;9(4):275-86 PMID: 6979537
Sch 34343 activity against streptococci and beta-lactam-resistant Enterobacteriaceae.
J Antimicrob Chemother. 1985 Jun;15 Suppl C:147-54 PMID: 3897168
[Distribution of constituent beta-lactamases in Pseudomonas aeruginosa].
Presse Med. 1984 Mar 29;13(13):772-6 PMID: 6231593
Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin.
Antimicrob Agents Chemother. 1984 Oct;26(4):580-2 PMID: 6097169
Kinetic studies on inactivation of Citrobacter freundii cephalosporinase by sulbactam.
Antimicrob Agents Chemother. 1983 Jul;24(1):23-30 PMID: 6312873

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.29.5.955

Published

1986-05-00

Pages

955-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC284193

Subset

External Links

PubMed source DOI: 10.1128/AAC.29.5.955 PMC Full Text View journal details

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Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases.

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