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PMID: 3135271 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of immunity with avirulent Listeria monocytogenes 19113 depends on bacterial replication.

Infection and immunity ·Vol. 56 ·No. 8 ·1988-08-00 ·Pages 2109-13

Baldridge JR, Thomashow MF, Hinrichs DJ

Abstract

Events necessary for triggering the cell-mediated response to intracellular parasites are poorly understood. Here we show that extremely high doses of avirulent Listeria monocytogenes 19113 (greater than 10(9] induce a modest and short-lived state of resistance in BALB/c mice. Induction of this protective state could not be achieved with nonviable bacteria and was blocked by inhibiting replication of viable L. monocytogenes 19113 through antibiotic treatment. The immune response was antigen specific and could be adoptively transferred with lymphoid cells. However, unlike the prototypic acquired cellular resistance induced by virulent Listeria strains, the protective response induced by L. monocytogenes 19113 was extremely short-lived, lasting less than 2 weeks, with a precipitous decline in the activity of the immune cells involved. An intervening in vitro culture period with concanavalin A greatly enhanced the activity of the adoptively transferred immune cells.

MeSH Terms
Animals Anti-Bacterial Agents/pharmacology Antigens, Bacterial/immunology Immunity Immunization Immunization, Passive Listeria monocytogenes/growth & development,immunology,pathogenicity Listeriosis/immunology,prevention & control Mice Mice, Inbred BALB C Spleen/immunology,microbiology
Chemicals
Anti-Bacterial Agents Antigens, Bacterial
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Baldridge J R
Department of Microbiology, Washington State University, Pullman 99164.
Thomashow M F
Hinrichs D J
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.8.2109-2113.1988
Published
1988-08-00
Pages
2109-13
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259530
Subset
IM
Grants
NIAID NIH HHS · AI23455 · United States
External Links
PubMed source DOI: 10.1128/iai.56.8.2109-2113.1988 PMC Full Text View journal details
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