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PMID: 16558105 Published · ppublish English Journal Article

Induction of Resistance by Listeria monocytogenes Cell Wall Fraction.

Infection and immunity ·Vol. 10 ·No. 5 ·1974-11-00 ·Pages 1163-9

Rodriguez GE, McClatchy JK, Campbell PA

Abstract

A crude cell wall fraction of Listeria monocytogenes was prepared by sonic disruption and differential centrifugation of viable, washed cultures. When injected into mice, this sterile, crude cell wall fraction protected mice against an intraperitoneal challenge with 18 to 85 50% mean lethal dose of L. monocytogenes. Resistance was greatly enhanced when bacterial endotoxin (lipopolysaccharide) was injected along with the cell wall fraction. Resistance was measured both by enumerating the bacteria in the livers and spleens of vaccinated and control mice and by survival studies. Two major lines of evidence suggest that the resistance induced by cell wall fraction is at least in part specific. Unlike non-specific resistance, the cell wall fraction-induced resistance was relatively long-lived, (i.e., it was demonstrable 6 weeks after the last injection of cell wall fraction and lipopolysaccharide). In addition, cell wall fraction protected against challenge with L. monocytogenes, but not against challenge with S. typhimurium.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rodriguez G E
Division of Allergy and Clinical Immunology, National Jewish Hospital and Research Center, Denver, Colorado 80206.
McClatchy J K
Campbell P A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.10.5.1163-1169.1974
Published
1974-11-00
Pages
1163-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC423077
External Links
PubMed source DOI: 10.1128/iai.10.5.1163-1169.1974 PMC Full Text View journal details
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