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PMID: 3127840 Published · ppublish English Journal Article Review

Is the forced swimming test a suitable model for revealing antidepressant activity?

Psychopharmacology ·Vol. 94 ·No. 2 ·1988-00-00 ·Pages 147-60

Borsini F, Meli A

Abstract

The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.

MeSH Terms
Animals Antidepressive Agents/pharmacology Depression/drug therapy,physiopathology Disease Models, Animal Mice Physical Exertion Rats Species Specificity Swimming
Chemicals
Antidepressive Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Borsini F
A. Menarini Pharmaceuticals, Research Department, Firenze, Italy.
Meli A
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00176837
Published
1988-00-00
Pages
147-60
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00176837 View journal details
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