U-43,465F: a triazolobenzodiazepine with pronounced antidepressant-like as well as anxiolytic activities in animals.

U-43,465F displays activity in a number of classical antidepressant assays in rodents. Mechanistically, it potentiates norepinephrine and blocks the uptake of this amine but not that of serotonin. It is not a monoamine oxidase inhibitor nor does it markedly enhance monamine release. In several behavioral assays based upon conditioned and non-conditioned behavioral suppression, U-43,465F displays anxiolytic properties. Thus this compound possesses both antidepressant-like and anxiolytic activities and may have a special utility in the treatment of depressive disorders.