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PMID: 3113784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

Clinical and experimental immunology ·Vol. 67 ·No. 1 ·1987-01-00 ·Pages 5-10

Playfair JH, De Souza JB

Abstract

Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneally or subcutaneously. Specific immune responses that were enhanced included antibody, T cell help, and delayed hypersensitivity.

MeSH Terms

Adjuvants, Immunologic Animals Antigens/therapeutic use Antigens, Protozoan/therapeutic use Female Histocompatibility Antigens Class II Hypersensitivity, Delayed/immunology Interferon-gamma/immunology Malaria/immunology,prevention & control Male Mice Recombinant Proteins/immunology Vaccines, Synthetic/therapeutic use

Chemicals

Adjuvants, Immunologic Antigens Antigens, Protozoan Histocompatibility Antigens Class II Recombinant Proteins Vaccines, Synthetic Interferon-gamma

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Playfair J H

De Souza J B

References (15)

15 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1987-01-00

Pages

5-10

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1542557

Subset

External Links

PubMed source PMC Full Text View journal details

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Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

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