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PMID: 3095630 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene.

Molecular and cellular biology ·Vol. 6 ·No. 3 ·1986-03-00 ·Pages 959-63

Wyke JA, Stoker AW, Searle S, Spooncer E, Simmons P, Dexter TM

Abstract

Multipotential stem cell lines, derived specifically from long-term bone marrow cultures infected with a recombinant retrovirus carrying v-src, lack v-src. Stable consequences thus result from transient actions or indirect effects of v-src on other cells, with the latter possibility being favored by its mosaic expression in marrow cultures.

MeSH Terms
Animals Bone Marrow Cells Cell Line Cell Transformation, Neoplastic Cells, Cultured Fluorescent Antibody Technique Genes Hematopoiesis Hematopoietic Stem Cells/cytology Mice Moloney murine leukemia virus/genetics Oncogene Protein pp60(v-src) Oncogenes Retroviridae Proteins/analysis,genetics
Chemicals
Retroviridae Proteins Oncogene Protein pp60(v-src)
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Wyke J A
Stoker A W
Searle S
Spooncer E
Simmons P
Dexter T M
References (21)
21 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.6.3.959-963.1986
Published
1986-03-00
Pages
959-63
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC367598
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.6.3.959-963.1986 PMC Full Text View journal details
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