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PMID: 30805892 Published · ppublish English Journal Article

Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.

Molecular biology reports ·Vol. 46 ·No. 3 ·2019-06-00 ·Pages 2693-2701

Zhou H, Cao T, Li WP, Wu G

Abstract

PPFIA family members and ALG3 play important roles in tumorigenesis and tumor progression. However, the exact roles of distinct PPFIA family members and ALG3 in head and neck squamous cell carcinoma (HNSCC) remain unclear. We studied the mRNA expressions of PPFIA family members and ALG3 in a variety of tumor types compared with the normal controls using the Oncomine database along with meta-analyses of their expressions in HNSCC cancer cell line. The mRNA expressions of PPFIA family members and ALG3 in laryngeal squamous cell carcinoma cell line and normal laryngeal cell line were detected by quantitative real-time polymerase chain reaction. Based on the cBioportal database, we further studied mRNA expression alterations and co-occurrence relationships of the PPFIA family members and ALG3 in HNSCC. The relationship between PPFIA1 and ALG3 mRNA expression alterations and prognoses in patients with HNSCC was explored. We found that PPFIA1 and ALG3 were distinctively overexpressed at the mRNA level in HNSCC tissues compared with normal tissues, they had a significant co-occurrence relationship, their mRNA expressions were significantly higher than other PPFIA family members in laryngeal squamous cell carcinoma cell line, and their mRNA expressions were also significantly higher in laryngeal carcinoma cell line than in normal laryngeal cell line. Patients without both PPFIA1 and ALG3 mRNA expression alterations had better overall survival and disease/progression-free survival compared with patients with both PPFIA1 and ALG3 alterations. Based on these findings, PPFIA1 and ALG3 may play roles in oncogene expression in HNSCC. Their combined overexpression is significantly associated with poor survival outcomes. The relationship between them and the mechanism of action in head and neck cancers deserve further investigation.

Keywords
ALG3 Head and neck cancer PPFIA1 Prognosis
MeSH Terms
Adaptor Proteins, Signal Transducing/genetics,metabolism,physiology Biomarkers, Tumor/genetics Carcinoma, Squamous Cell/genetics Cell Line, Tumor Cell Proliferation/genetics Cell Transformation, Neoplastic/genetics Databases, Genetic Gene Expression Regulation, Neoplastic/genetics Head and Neck Neoplasms/genetics Humans Laryngeal Neoplasms/genetics Mannosyltransferases/genetics,metabolism,physiology Prognosis Real-Time Polymerase Chain Reaction Squamous Cell Carcinoma of Head and Neck/genetics,metabolism Transcriptome/genetics
Chemicals
Adaptor Proteins, Signal Transducing Biomarkers, Tumor PPFIA1 protein, human ALG3 protein, human Mannosyltransferases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zhou Hong
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.
Cao Ting
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.
Li Wen Ping
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.
Wu Gang ORCID
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China. wghmqsh@163.com.
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Article Info
Journal
Molecular biology reports
Abbr.
Mol Biol Rep
ISSN
1573-4978
DOI
10.1007/s11033-019-04712-y
Email
wghmqsh@163.com
Published
2019-06-00
Epub
2019-00-25
Pages
2693-2701
Language
English
Region
Netherlands
NLM ID
0403234
Subset
IM
Grants
Shanghai Pudong Hospital Talent Introduction Program · 2015YJ-07
External Links
PubMed source DOI: 10.1007/s11033-019-04712-y View journal details
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