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PMID: 3045005 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence of streptococcal pyrogenic exotoxin type C.

Infection and immunity ·Vol. 56 ·No. 9 ·1988-09-00 ·Pages 2518-20

Goshorn SC, Schlievert PM

Abstract

The nucleotide sequence of the gene speC, encoding streptococcal pyrogenic exotoxin type C (SPE C), was determined. The gene encoded a mature protein of 208 amino acids, with a calculated molecular weight of 24,354. The mature amino acid sequence of SPE C was analyzed for homology with the amino acid sequences of streptococcal pyrogenic exotoxin type A, the staphylococcal enterotoxins, and toxic shock syndrome toxin-1. Of these, SPE C shared the greatest amount of homology with streptococcal exotoxin type A.

MeSH Terms
Amino Acid Sequence Bacterial Proteins Base Sequence Cloning, Molecular Exotoxins/genetics,isolation & purification Membrane Proteins Molecular Sequence Data Sequence Homology, Nucleic Acid Streptococcus pyogenes/genetics
Chemicals
Bacterial Proteins Exotoxins Membrane Proteins SpeA protein, Streptococcus pyogenes erythrogenic toxin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goshorn S C
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.
Schlievert P M
References (21)
21 references, click to expand
  1. Production of pyrogenic exotoxin by groups of streptococci: association with group A.
    J Infect Dis. 1979 Nov;140(5):676-81 PMID: 393776
  2. Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.
    Gene. 1977;2(2):95-113 PMID: 344137
  3. Rapid similarity searches of nucleic acid and protein data banks.
    Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30 PMID: 6572363
  4. New M13 vectors for cloning.
    Methods Enzymol. 1983;101:20-78 PMID: 6310323
  5. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage.
    Nature. 1983 Oct 20-26;305(5936):709-12 PMID: 6226876
  6. Group A streptococcal phage T12 carries the structural gene for pyrogenic exotoxin type A.
    Mol Gen Genet. 1984;194(1-2):52-6 PMID: 6374381
  7. Penicillinase plasmid-linked genetic determinants for enterotoxins B and C1 production in Staphylococcus aureus.
    Infect Immun. 1985 Feb;47(2):514-21 PMID: 3871425
  8. A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.
    Plasmid. 1985 Jan;13(1):31-40 PMID: 3991809
  9. Staphylococcal enterotoxin A is encoded by phage.
    Science. 1985 Jul 12;229(4709):185-7 PMID: 3160112
  10. Molecular cloning of staphylococcal enterotoxin B gene in Escherichia coli and Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5850-4 PMID: 3898073
  11. Nucleotide sequence of the type A streptococcal exotoxin (erythrogenic toxin) gene from Streptococcus pyogenes bacteriophage T12.
    Infect Immun. 1986 Apr;52(1):144-50 PMID: 3514452
  12. Nucleotide sequence of the enterotoxin B gene from Staphylococcus aureus.
    J Bacteriol. 1986 Apr;166(1):29-33 PMID: 3957869
  13. The nucleotide and partial amino acid sequence of toxic shock syndrome toxin-1.
    J Biol Chem. 1986 Nov 25;261(33):15783-6 PMID: 3782090
  14. Expression of staphylococcal enterotoxin C1 in Escherichia coli.
    Infect Immun. 1987 Feb;55(2):428-32 PMID: 3542834
  15. Optimal sequence alignment using affine gap costs.
    Bull Math Biol. 1986;48(5-6):603-16 PMID: 3580642
  16. Clinical and bacteriologic observations of a toxic shock-like syndrome due to Streptococcus pyogenes.
    N Engl J Med. 1987 Jul 16;317(3):146-9 PMID: 3299086
  17. Nucleotide sequence of the staphylococcal enterotoxin C1 gene and relatedness to other pyrogenic toxins.
    Mol Gen Genet. 1987 Aug;209(1):15-20 PMID: 2823067
  18. Nucleotide sequence of the type A staphylococcal enterotoxin gene.
    J Bacteriol. 1988 Jan;170(1):34-41 PMID: 3335483
  19. Cross-neutralization of staphylococcal and streptococcal pyrogenic toxins by monoclonal and polyclonal antibodies.
    Infect Immun. 1988 Feb;56(2):400-4 PMID: 2448242
  20. Cloning and characterization of the gene, speC, for pyrogenic exotoxin type C from Streptococcus pyogenes.
    Mol Gen Genet. 1988 Apr;212(1):66-70 PMID: 2836707
  21. Regulatory sequences involved in the promotion and termination of RNA transcription.
    Annu Rev Genet. 1979;13:319-53 PMID: 94251
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.9.2518-2520.1988
Published
1988-09-00
Pages
2518-20
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259600
Subset
IM
Grants
NCI NIH HHS · 5T32 CA09138 · United States
NHLBI NIH HHS · HL36611 · United States
External Links
PubMed source DOI: 10.1128/iai.56.9.2518-2520.1988 PMC Full Text View journal details
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