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PMID: 3012118 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

AKR ecotropic murine leukemia virus SL3-3 forms envelope gene recombinants in vivo.

Journal of virology ·Vol. 59 ·No. 1 ·1986-07-00 ·Pages 23-30

Thomas CY

Abstract

The ecotropic AKR virus SL3-3 was injected into neonatal mice of the high-leukemia strains HRS/J and CWD/J and the low-leukemia strains CBA/J, SEA/J, and NIH Swiss. SL3-3 was highly leukemogenic in each strain, and 90% of the inoculated animals died by 6 months of age. T1 oligonucleotide fingerprint analysis of the genomic RNAs of viruses recovered from 9 of 13 leukemic animals revealed the presence of the SL3-3 virus and recombinant viruses with polytropic virus-related envelope gene sequences. Recombinant proviruses were detected by the Southern blot technique in the DNAs of 17 of 18 tumors. The pattern of substitutions within the envelope genes of the SL3-3 recombinant viruses appeared to be dependent on the strain of the animal. These observations indicate that the SL3-3 virus formed envelope gene recombinants in vivo in each of the strains that were studied. However, the role of these recombinants during leukemogenesis remains to be defined.

MeSH Terms
AKR murine leukemia virus/genetics Animals Cell Transformation, Viral DNA, Neoplasm/genetics Genes, Viral Leukemia Virus, Murine/genetics Leukemia, Experimental/microbiology Mice Mice, Inbred Strains Oligoribonucleotides/analysis RNA, Viral/genetics Recombination, Genetic Viral Envelope Proteins/genetics
Chemicals
DNA, Neoplasm Oligoribonucleotides RNA, Viral Viral Envelope Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Thomas C Y
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35 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.59.1.23-30.1986
Published
1986-07-00
Pages
23-30
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253033
Subset
IM
Grants
NCI NIH HHS · R01 CA 32995 · United States
External Links
PubMed source DOI: 10.1128/JVI.59.1.23-30.1986 PMC Full Text View journal details
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