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PMID: 3006857 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Kadsurenone distinguishes between different platelet activating factor receptor subtypes on macrophages and polymorphonuclear leucocytes.

British journal of pharmacology ·Vol. 87 ·No. 2 ·1986-02-00 ·Pages 287-9

Lambrecht G, Parnham MJ

Abstract

The effects of the antagonist kadsurenone on the platelet activating factor (Paf)-induced chemiluminescence of guinea-pig peritoneal macrophages and on pig peripheral blood leucocyte aggregation were compared. Linearity and slopes of unity of the Schild plots confirmed the competitive nature of the antagonism by kadsurenone. pA2 values indicated a 91 fold lower affinity of kadsurenone for leucocyte Paf receptors than for those in macrophages. It is concluded that these two types of Paf receptors are not identical and are provisionally designated Paf1 and Paf2 receptors, respectively.

MeSH Terms
Animals Benzofurans Benzopyrans/pharmacology Cell Aggregation/drug effects Guinea Pigs Lignans Luminescent Measurements Macrophages/metabolism Male Neutrophils/metabolism Platelet Membrane Glycoproteins Receptors, Cell Surface/classification,drug effects Receptors, G-Protein-Coupled Swine
Chemicals
Benzofurans Benzopyrans Lignans Platelet Membrane Glycoproteins Receptors, Cell Surface Receptors, G-Protein-Coupled platelet activating factor receptor kadsurenone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lambrecht G
Parnham M J
References (8)
8 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1986.tb10816.x
Published
1986-02-00
Pages
287-9
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1916546
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1986.tb10816.x PMC Full Text View journal details
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