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PMID: 3003591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Islet-activating protein (pertussis toxin) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 331 ·No. 2-3 ·1985-11-00 ·Pages 235-9

Allgaier C, Feuerstein TJ, Jackisch R, Hertting G

Abstract

The effect of islet-activating protein (IAP) on alpha 2-adrenoceptor mediated modulation of noradrenaline release in the rabbit hippocampus was studied. Slices of the hippocampus were incubated for 6 h with IAP, subsequently loaded with 3H-noradrenaline and superfused continuously. IAP-pretreatment significantly enhanced the electrically evoked transmitter release and diminished the facilitatory effect of the alpha 2-adrenoceptor antagonist yohimbine. In addition, the inhibitory effect of the alpha 2-adrenoceptor agonist clonidine was reduced. These results provide circumstantial evidence that an inhibitory guanine-nucleotide-binding protein, most probably Ni of a presynaptically located adenylate cyclase, is involved in the alpha 2-autoreceptor mediated modulation of noradrenaline release.

MeSH Terms
Adenylate Cyclase Toxin Animals Clonidine/pharmacology Cyclic AMP/physiology Electric Stimulation Hemagglutination Tests Hippocampus/drug effects,metabolism In Vitro Techniques Norepinephrine/metabolism Pertussis Toxin Rabbits Receptors, Adrenergic, alpha/drug effects Virulence Factors, Bordetella/pharmacology Yohimbine/pharmacology
Chemicals
Adenylate Cyclase Toxin Receptors, Adrenergic, alpha Virulence Factors, Bordetella Yohimbine Cyclic AMP Pertussis Toxin Clonidine Norepinephrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Allgaier C
Feuerstein T J
Jackisch R
Hertting G
References (38)
38 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00634243
Published
1985-11-00
Pages
235-9
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00634243 View journal details
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