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PMID: 3003369 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Comparison of human and chimpanzee zeta 1 globin genes.

Journal of molecular evolution ·Vol. 22 ·No. 4 ·1985-00-00 ·Pages 309-15

Willard C, Wong E, Hess JF, Shen CK, Chapman B, Wilson AC, Schmid CW

Abstract

The DNA base sequences of the entire chimpanzee zeta 1 globin gene and an additional 1 kb of DNA flanking both the human and chimpanzee genes have been determined. Whereas the human zeta 1 gene contains a termination codon in the sixth position, the chimpanzee gene appears to be functional. This finding confirms Proudfoot et al.'s suggestion that the human zeta 1 gene was recently inactivated. Like the corresponding human zeta 1 and zeta 2 genes, the first and second introns of the chimpanzee zeta 1 gene are occupied largely by tandem repeats of short oligonucleotides. These tandem repeats have undergone several rearrangements since the divergence of the human and chimpanzee zeta 1 genes.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Cloning, Molecular Codon DNA Restriction Enzymes Genes Globins/genetics Humans Pan troglodytes Plasmids Species Specificity
Chemicals
Codon Globins DNA Restriction Enzymes
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Willard C
Wong E
Hess J F
Shen C K
Chapman B
Wilson A C
Schmid C W
References (23)
23 references, click to expand
  1. Hypervariable 'minisatellite' regions in human DNA.
    Nature. 1985 Mar 7-13;314(6006):67-73 PMID: 3856104
  2. The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.
    Cell. 1980 May;20(1):119-30 PMID: 6446404
  3. Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee.
    J Mol Biol. 1984 Dec 25;180(4):767-84 PMID: 6098690
  4. A mouse type 2 Alu sequence (M2) is mobile in the genome.
    Nature. 1983 Jan 6;301(5895):87-9 PMID: 6296687
  5. A system for shotgun DNA sequencing.
    Nucleic Acids Res. 1981 Jan 24;9(2):309-21 PMID: 6259625
  6. The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.
    Cell. 1980 Sep;21(2):537-44 PMID: 7407925
  7. The nucleotide sequence of a rabbit beta-globin pseudogene.
    Cell. 1980 Sep;21(2):545-53 PMID: 7407926
  8. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.
    Nature. 1982 Jan 7;295(5844):31-5 PMID: 7035959
  9. Repetitive satellite-like sequences are present within or upstream from 3 avian protein-coding genes.
    Nucleic Acids Res. 1983 Mar 11;11(5):1227-43 PMID: 6828383
  10. The ovalbumin gene family. The 5' end region of the X and Y genes.
    J Mol Biol. 1982 Mar 25;156(1):1-19 PMID: 6178832
  11. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene.
    Cell. 1982 Dec;31(3 Pt 2):553-63 PMID: 6297773
  12. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  13. The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization.
    J Mol Evol. 1984;20(1):2-15 PMID: 6429338
  14. Rise and fall of the delta globin gene.
    J Mol Biol. 1983 Mar 15;164(4):513-28 PMID: 6188843
  15. Intergenic DNA sequences flanking the pseudo alpha globin genes of human and chimpanzee.
    Nucleic Acids Res. 1983 Nov 25;11(22):8087-101 PMID: 6316284
  16. Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.
    Proc Natl Acad Sci U S A. 1980 Apr;77(4):2158-62 PMID: 6929543
  17. Transcriptional analysis of human zeta globin genes.
    EMBO J. 1984 Jul;3(7):1533-40 PMID: 6745241
  18. Novel repetitive sequence families showing size and frequency polymorphism in the genomes of mice.
    J Mol Biol. 1983 Apr 5;165(2):209-28 PMID: 6302286
  19. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.
    Cell. 1983 Jul;33(3):729-40 PMID: 6409418
  20. A new method for sequencing DNA.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 PMID: 265521
  21. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.
    Cell. 1983 Jul;33(3):717-28 PMID: 6409417
  22. Evolution of Alu family repeats since the divergence of human and chimpanzee.
    J Mol Evol. 1985;22(4):316-22 PMID: 3003370
  23. The primate psi beta 1 gene. An ancient beta-globin pseudogene.
    J Mol Biol. 1984 Dec 25;180(4):785-801 PMID: 6527389
Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02115686
Published
1985-00-00
Pages
309-15
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
Grants
NIADDK NIH HHS · AM 29800 · United States
NIGMS NIH HHS · GM 21346 · United States
Databases
GENBANK
X03234
External Links
PubMed source DOI: 10.1007/BF02115686 View journal details
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