Mapping of the X-linked agammaglobulinemia locus by use of restriction fragment-length polymorphism.
A molecular linkage analysis in 11 families with X-linked agammaglobulinemia (XLA) localized the XLA gene to the proximal part of the long arm of the human X chromosome. Significant linkage was detected between XLA and loci defined by two polymorphic DNA probes called 19-2 for the DXS3 locus and S21 for the DXS17 locus. Both localize to the region Xq21.3-Xq22. Most likely recombination distances (theta) and associated logarithm of the odds (lod) scores for the XLA-DXS3 and XLA-DXS17 pairs were theta = 0.04 morgans (lod, 3.65) and theta = 0 (lod, 2.17), respectively. Tight linkage between XLA and the locus DXS43 defined by the X short arm probe D2 (localized to Xp22-Xp21) was strongly excluded and we obtained no evidence for significant linkage between XLA and any other X short arm probe. The probe pair 19-2 and S21 should be informative for molecular linkage-based analysis of XLA segregation in the majority of families afflicted with this disorder.
25 references, click to expand
-
An RFLP detecting single copy X-chromosome fragment, dic56, from Xp22-Xpter [HGM8 assignment no. DXS 143].Nucleic Acids Res. 1985 Aug 12;13(15):5723 PMID: 2994010
-
Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome.Nucleic Acids Res. 1983 Apr 25;11(8):2303-12 PMID: 6304647
-
Detection of specific sequences among DNA fragments separated by gel electrophoresis.J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
-
Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.Proc Natl Acad Sci U S A. 1977 Mar;74(3):1245-9 PMID: 265567
-
B lymphocyte precursors in human bone marrow: an analysis of normal individuals and patients with antibody-deficiency states.J Immunol. 1978 Apr;120(4):1169-75 PMID: 346998
-
Inherited interstitial del(Xp) with minimal clinical consequences: with a note on the location of genes controlling phenotypic features.Am J Med Genet. 1979;3(1):43-58 PMID: 474618
-
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.Am J Hum Genet. 1980 May;32(3):314-31 PMID: 6247908
-
Linkage analysis in man.Adv Hum Genet. 1980;10:209-66 PMID: 6994459
-
Immunodeficiency associated with a deletion in the short arm of the X-chromosome.Clin Exp Immunol. 1981 Jul;45(1):107-12 PMID: 7307343
-
Regional localization on the human X of DNA segments cloned from flow sorted chromosomes.Nucleic Acids Res. 1982 Mar 11;10(5):1557-78 PMID: 6461845
-
Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.Nature. 1982 Nov 4;300(5887):69-71 PMID: 6982420
-
Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes.Proc Natl Acad Sci U S A. 1982 Sep;79(17):5352-6 PMID: 6291041
-
Primary immunodeficiency diseases. Report prepared for the WHO by a scientific group on immunodeficiency.Clin Immunol Immunopathol. 1983 Sep;28(3):450-75 PMID: 6349887
-
Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.Proc Natl Acad Sci U S A. 1983 Jan;80(2):472-6 PMID: 6188151
-
Interstitial deletion in the "critical region" of the long arm of the X chromosome in a mentally retarded boy and his normal mother.Hum Genet. 1983;64(2):196-9 PMID: 6885061
-
Defective B cell function associated with inherited interstitial deletion of the short arm of the X chromosome.J Immunol. 1983 Sep;131(3):1218-21 PMID: 6224853
-
Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.Proc Natl Acad Sci U S A. 1984 May;81(9):2836-9 PMID: 6326147
-
Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase.Science. 1984 Jun 8;224(4653):1068-74 PMID: 6372096
-
A strategy to reveal high-frequency RFLPs along the human X chromosome.Am J Hum Genet. 1984 May;36(3):546-64 PMID: 6328976
-
The primary immunodeficiencies (1).N Engl J Med. 1984 Jul 26;311(4):235-42 PMID: 6234467
-
Inherited chondrodysplasia punctata due to a deletion of the terminal short arm of an X chromosome.N Engl J Med. 1984 Oct 18;311(16):1010-5 PMID: 6482910
-
Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome.Am J Hum Genet. 1985 Mar;37(2):250-67 PMID: 4039107
-
X-linked agammaglobulinemia: an analysis of 96 patients.Medicine (Baltimore). 1985 May;64(3):145-56 PMID: 2581110
-
Mapping DNA sequences in a human X-chromosome deletion which extends across the region of the Duchenne muscular dystrophy mutation.Am J Hum Genet. 1985 May;37(3):451-62 PMID: 2988331
-
Identification and characterization of subpopulations of lymphocytes in human peripheral blood after fractionation on discontinuous gradients of albumin. The cellular defect in X-linked agammaglobulinemia.J Clin Invest. 1973 Jul;52(7):1726-34 PMID: 4578158
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