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PMID: 2993156 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An EcoRI restriction fragment length polymorphism (RFLP) in the human c-erb A locus.

Human genetics ·Vol. 71 ·No. 1 ·1985-00-00 ·Pages 41-4

Mathieu-Mahul D, Xu DQ, Saule S, Lidereau R, Galibert F, Berger R, Mauchauffé M, Larsen CJ

Abstract

An EcoRI restriction fragment length polymorphism (RFLP) was detected in the 3' end of the locus of the c-erb-A proto-oncogene. The frequency of the rarer allele was around 3.0% in a normal population of 107 unrelated individuals. This frequency did not significantly differ in DNA samples from patients with breast tumors or acute leukemias.

MeSH Terms
Alpharetrovirus/genetics Avian Leukosis Virus/genetics Breast Neoplasms/genetics Chromosome Mapping Cloning, Molecular DNA Restriction Enzymes DNA, Neoplasm/genetics Deoxyribonuclease EcoRI Female Humans Leukemia/genetics Male Nucleic Acid Hybridization Oncogenes Pedigree Polymorphism, Genetic Proto-Oncogene Mas
Chemicals
DNA, Neoplasm MAS1 protein, human Proto-Oncogene Mas DNA Restriction Enzymes Deoxyribonuclease EcoRI
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Mathieu-Mahul D
Xu D Q
Saule S
Lidereau R
Galibert F
Berger R
Mauchauffé M
Larsen C J
References (16)
16 references, click to expand
  1. Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients.
    Proc Natl Acad Sci U S A. 1985 Oct;82(20):7068-70 PMID: 2996003
  2. Human c-fms proto-oncogene: comparative analysis with an abnormal allele.
    Mol Cell Biol. 1985 Feb;5(2):422-6 PMID: 3974576
  3. Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.
    Proc Natl Acad Sci U S A. 1982 Jul;79(13):4078-82 PMID: 6287464
  4. Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.
    Nature. 1985 Jan 31-Feb 6;313(6001):369-74 PMID: 2578622
  5. Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation.
    Nature. 1979 Oct 11;281(5731):452-5 PMID: 226888
  6. Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes.
    Cell. 1983 Jan;32(1):227-38 PMID: 6297784
  7. Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene.
    Science. 1984 Jun 29;224(4656):1456-9 PMID: 6328658
  8. A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas.
    Cell. 1983 Aug;34(1):225-32 PMID: 6309409
  9. A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
    Proc Natl Acad Sci U S A. 1984 Jul;81(14):4495-9 PMID: 6589608
  10. Avian leukemia viruses: interaction with their target cells in vivo and in vitro.
    Biochim Biophys Acta. 1978 Nov 17;516(3):269-99 PMID: 215208
  11. Isolation and characterization of multiple human genes homologous to the oncogenes of avian erythroblastosis virus.
    EMBO J. 1983;2(4):561-5 PMID: 6313346
  12. Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb-B polypeptide.
    Proc Natl Acad Sci U S A. 1982 Jul;79(13):3958-62 PMID: 6287456
  13. Characterization of the oncogene (erb) of avian erythroblastosis virus and its cellular progenitor.
    J Virol. 1981 May;38(2):409-19 PMID: 6264118
  14. Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.
    EMBO J. 1984 Feb;3(2):383-7 PMID: 6714223
  15. Restriction fragment length polymorphism of the human c-fms gene.
    Proc Natl Acad Sci U S A. 1985 May;82(9):2862-5 PMID: 2986142
  16. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.
    Nature. 1984 Feb 9-15;307(5951):521-7 PMID: 6320011
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00295666
Published
1985-00-00
Pages
41-4
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00295666 View journal details
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