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PMID: 2991119 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13.

Human genetics ·Vol. 70 ·No. 4 ·1985-00-00 ·Pages 344-6

Raizis AM, Becroft DM, Shaw RL, Reeve AE

Abstract

Wilms tumor is believed to occur as the result of two mutations affecting both alleles of a critical gene located within the p13 band of chromosome 11 (Knudson and Strong 1972; Riccardi et al. 1978). Several mechanisms by which these mutations occur have already been determined in retinoblastoma (Cavenee et al. 1983) and Wilms tumor (Koufos et al. 1984; Orkin et al. 1984; Reeve et al. 1984; Fearon et al. 1984a; Eccles et al. 1984). Of the various mechanisms, however, no example of a mitotic recombination was demonstrated in Wilms tumor. An example is presented here which has been detected by the use of restriction fragment length polymorphisms (RFLPs) mapping to chromosome 11p. In addition the data presented are consistent with the mapping location of parathyroid hormone (PTH) being proximal to 11p13.

MeSH Terms
Chromosome Mapping Chromosomes, Human, 6-12 and X Genetic Markers Humans Kidney Neoplasms/genetics Mitosis Parathyroid Hormone/genetics Recombination, Genetic Wilms Tumor/genetics
Chemicals
Genetic Markers Parathyroid Hormone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Raizis A M
Becroft D M
Shaw R L
Reeve A E
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25 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00295375
Published
1985-00-00
Pages
344-6
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00295375 View journal details
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