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PMID: 2987840 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of replication, and the BK virus enhancer.

Nucleic acids research ·Vol. 13 ·No. 6 ·1985-03-25 ·Pages 2045-61

Nowock J, Borgmeyer U, Püschel AW, Rupp RA, Sippel AE

Abstract

TGGCA-binding proteins are nuclear proteins with high affinity for double-stranded DNA homologous to the prototype recognition sequence 5'YTGGCANNNTGCCAR 3'. Their ubiquitous tissue distribution in higher vertebrates characterizes them as a class of highly conserved proteins which may exert a basic function. To obtain clues to this function, specific binding sites were mapped on three viral genomes. Recognition sites were identified in the enhancer region of the BK virus, in the LTR of the mouse mammary tumor virus, and in the origin of replication of adenovirus 12. The TGGCA-binding protein from HeLa cells appears to be identical to nuclear factor I described by others, which stimulates initiation of adenovirus DNA replication in vitro. However, data from MMTV, BKV, and from cellular genes suggest that this specific protein-DNA interaction may also be involved in the control of gene activity.

MeSH Terms
Adenoviruses, Human/genetics Animals BK Virus/genetics Base Sequence CCAAT-Enhancer-Binding Proteins Chromatin/physiology,ultrastructure DNA, Viral/genetics,metabolism DNA-Binding Proteins/metabolism Enhancer Elements, Genetic Gene Expression Regulation Genes, Regulator Humans Mammary Tumor Virus, Mouse/genetics Mice NFI Transcription Factors Nuclear Proteins Species Specificity Transcription Factors Y-Box-Binding Protein 1
Chemicals
CCAAT-Enhancer-Binding Proteins Chromatin DNA, Viral DNA-Binding Proteins NFI Transcription Factors Nuclear Proteins Transcription Factors Y-Box-Binding Protein 1 YBX1 protein, human
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Nowock J
Borgmeyer U
Püschel A W
Rupp R A
Sippel A E
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/13.6.2045
Published
1985-03-25
Pages
2045-61
Language
English
Region
England
NLM ID
0411011
PMCID
PMC341134
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/13.6.2045 PMC Full Text View journal details
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