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PMID: 2986145 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 9 ·1985-05-00 ·Pages 2910-4

Mengle-Gaw L, McDevitt HO

Abstract

Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. We have isolated and determined the nucleotide sequences of cDNA and genomic clones for the I-E beta s gene and we present the predicted protein sequence for most of the E beta s polypeptide chain. The E beta s polypeptide shows 95% protein homology to the other cloned E beta alleles. Comparison of the protein sequences of five E beta alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E beta hypervariable regions may determine responsiveness to this antigen.

MeSH Terms
Alleles Amino Acid Sequence Animals Base Sequence Chromosome Mapping Cloning, Molecular Columbidae Cytochrome c Group/pharmacology DNA/genetics Genes Genes, MHC Class II Histocompatibility Antigens Class II/genetics Mice
Chemicals
Cytochrome c Group Histocompatibility Antigens Class II DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mengle-Gaw L
McDevitt H O
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33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.9.2910
Published
1985-05-00
Pages
2910-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397676
Subset
IM
Grants
NIAID NIH HHS · AI 07757 · United States
NCI NIH HHS · CA 09302 · United States
Databases
GENBANK
M11355
External Links
PubMed source DOI: 10.1073/pnas.82.9.2910 PMC Full Text View journal details
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