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PMID: 2964640 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 6 ·1988-03-00 ·Pages 1907-11

Shimizu A, Tepler I, Benfey PN, Berenstein EH, Siraganian RP, Leder P

Abstract

We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat alpha subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA/metabolism Humans Mast Cells/metabolism Molecular Sequence Data Peptide Mapping Rats Receptors, Fc/metabolism Receptors, IgE
Chemicals
Receptors, Fc Receptors, IgE DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Shimizu A
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115.
Tepler I
Benfey P N
Berenstein E H
Siraganian R P
Leder P
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.6.1907
Published
1988-03-00
Pages
1907-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC279890
Subset
IM
Grants
NIDDK NIH HHS · K12DK01401 · United States
Databases
GENBANK
J03605, J03606
External Links
PubMed source DOI: 10.1073/pnas.85.6.1907 PMC Full Text View journal details
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