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PMID: 29560185 Published · ppublish English Journal Article

Visible light C-H amidation of heteroarenes with benzoyl azides.

Chemical science ·Vol. 6 ·No. 2 ·2015-02-01 ·Pages 987-992

Brachet E, Ghosh T, Ghosh I, König B

Abstract

Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for heteroarenes, including pyrroles, indole, furan, benzofuran and thiophene giving good regio-selectivities and yields.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brachet E
University of Regensburg Faculty of Chemistry and Pharmacy , Institute of Organic Chemistry , Universitätsstraße 31 , 93053 Regensburg , Germany . Email: Burkhard.Koenig@chemie.uni-regensburg.de.
Ghosh T
University of Regensburg Faculty of Chemistry and Pharmacy , Institute of Organic Chemistry , Universitätsstraße 31 , 93053 Regensburg , Germany . Email: Burkhard.Koenig@chemie.uni-regensburg.de.
Ghosh I
University of Regensburg Faculty of Chemistry and Pharmacy , Institute of Organic Chemistry , Universitätsstraße 31 , 93053 Regensburg , Germany . Email: Burkhard.Koenig@chemie.uni-regensburg.de.
König B
University of Regensburg Faculty of Chemistry and Pharmacy , Institute of Organic Chemistry , Universitätsstraße 31 , 93053 Regensburg , Germany . Email: Burkhard.Koenig@chemie.uni-regensburg.de.
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Article Info
Journal
Chemical science
Abbr.
Chem Sci
ISSN
2041-6520
DOI
10.1039/c4sc02365j
Email
burkhard.koenig@chemie.uni-regensburg.de
Published
2015-02-01
Epub
2014-00-30
Pages
987-992
Language
English
Region
England
NLM ID
101545951
PMCID
PMC5811135
External Links
PubMed source DOI: 10.1039/c4sc02365j PMC Full Text View journal details
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